Association Between Clinical Severity of Childhood Asthma and Serum Leptin Levels

Objective To investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma correlates with body mass index (BMI) or serum leptin levels and to examine the sensitivity of leptin levels in predicting asthma severity. Met...

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Published inIndian journal of pediatrics Vol. 78; no. 3; pp. 291 - 295
Main Authors Tanju, Asya, Cekmez, Ferhat, Aydinoz, Secil, Karademir, Ferhan, Suleymanoglu, Selami, Gocmen, Ismail
Format Journal Article
LanguageEnglish
Published India Springer-Verlag 01.03.2011
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Abstract Objective To investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma correlates with body mass index (BMI) or serum leptin levels and to examine the sensitivity of leptin levels in predicting asthma severity. Methods This study was conducted in 65 patients, aged 2 to 14 yrs with newly diagnosed asthma without any chronic co-morbidity. The subjects were distributed into three groups according to the severity of asthma. Results Intra-group serum leptin levels before and after treatment did not show significant difference ( p  > 0.05). Inter-group pre-treatment leptin levels were different significantly ( p  < 0.01) and the difference originated from Group I and III as well as Group II and III. No correlation existed between leptin levels and BMI ( p  > 0.05). Conclusions Leptin levels correlated with the clinical severity of asthma and this was suggested to be associated with the severity of inflammation in asthma. More studies are required to evaluate leptin levels in predicting asthma severity.
AbstractList OBJECTIVETo investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma correlates with body mass index (BMI) or serum leptin levels and to examine the sensitivity of leptin levels in predicting asthma severity. METHODSThis study was conducted in 65 patients, aged 2 to 14 yrs with newly diagnosed asthma without any chronic co-morbidity. The subjects were distributed into three groups according to the severity of asthma. RESULTSIntra-group serum leptin levels before and after treatment did not show significant difference (p>0.05). Inter-group pre-treatment leptin levels were different significantly (p<0.01) and the difference originated from Group I and III as well as Group II and III. No correlation existed between leptin levels and BMI (p>0.05). CONCLUSIONSLeptin levels correlated with the clinical severity of asthma and this was suggested to be associated with the severity of inflammation in asthma. More studies are required to evaluate leptin levels in predicting asthma severity.
To investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma correlates with body mass index (BMI) or serum leptin levels and to examine the sensitivity of leptin levels in predicting asthma severity. This study was conducted in 65 patients, aged 2 to 14 yrs with newly diagnosed asthma without any chronic co-morbidity. The subjects were distributed into three groups according to the severity of asthma. Intra-group serum leptin levels before and after treatment did not show significant difference (p>0.05). Inter-group pre-treatment leptin levels were different significantly (p<0.01) and the difference originated from Group I and III as well as Group II and III. No correlation existed between leptin levels and BMI (p>0.05). Leptin levels correlated with the clinical severity of asthma and this was suggested to be associated with the severity of inflammation in asthma. More studies are required to evaluate leptin levels in predicting asthma severity.
Objective To investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma correlates with body mass index (BMI) or serum leptin levels and to examine the sensitivity of leptin levels in predicting asthma severity. Methods This study was conducted in 65 patients, aged 2 to 14 yrs with newly diagnosed asthma without any chronic co-morbidity. The subjects were distributed into three groups according to the severity of asthma. Results Intra-group serum leptin levels before and after treatment did not show significant difference ( p  > 0.05). Inter-group pre-treatment leptin levels were different significantly ( p  < 0.01) and the difference originated from Group I and III as well as Group II and III. No correlation existed between leptin levels and BMI ( p  > 0.05). Conclusions Leptin levels correlated with the clinical severity of asthma and this was suggested to be associated with the severity of inflammation in asthma. More studies are required to evaluate leptin levels in predicting asthma severity.
Author Tanju, Asya
Cekmez, Ferhat
Suleymanoglu, Selami
Gocmen, Ismail
Aydinoz, Secil
Karademir, Ferhan
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  surname: Gocmen
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  organization: Department of Pediatrics, GATA Haydarpasa Teaching Hospital
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Issue 3
Keywords Obesity
Leptin
Asthma
Human
Lung disease
Pediatrics
Respiratory disease
Nutrition disorder
Bronchus disease
Tropical medicine
Serum
Obstructive pulmonary disease
Child
Nutritional status
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Snippet Objective To investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma...
To investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma correlates...
OBJECTIVETo investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma...
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StartPage 291
SubjectTerms Adolescent
Asthma - blood
Asthma - diagnosis
Asthma - drug therapy
Biological and medical sciences
Biomarkers - blood
Body Mass Index
Child
Child, Preschool
Chronic obstructive pulmonary disease, asthma
Female
General aspects
Gynecology
Humans
Leptin - blood
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic diseases
Obesity
Original Article
Pediatrics
Pneumology
Sensitivity and Specificity
Severity of Illness Index
Title Association Between Clinical Severity of Childhood Asthma and Serum Leptin Levels
URI https://link.springer.com/article/10.1007/s12098-010-0281-0
https://www.ncbi.nlm.nih.gov/pubmed/20978869
https://search.proquest.com/docview/855207028
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