High-throughput methods for combinatorial drug discovery

• Published in: Science translational medicine Vol. 5; no. 205; p. 205rv1
• Main Authors: Sun, Xiaochen, Vilar, Santiago, Tatonetti, Nicholas P
• Format: Journal Article
• Language: English
• Published: United States 02.10.2013
• Subjects: Animals; Combinatorial Chemistry Techniques - methods; Computational Biology; Drug Discovery; Drug Therapy, Combination; High-Throughput Screening Assays - methods; Humans; Systems Biology

A more nuanced approach to drug design is to use multiple drugs in combination to target interacting or complementary pathways. Drug combination treatments have shown higher efficacy, fewer side effects, and less toxicity compared to single-drug treatment. In this Review, we focus on the use of high...