Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits
Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+...
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| Published in | Nature neuroscience Vol. 6; no. 9; pp. 911 - 912 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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United States
Nature Publishing Group
01.09.2003
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| Abstract | Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task. |
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| AbstractList | Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task. |
| Audience | Academic |
| Author | Kye, Min-Jeong Radulovic, Jelena Nijholt, Ingrid Blank, Thomas Spiess, Joachim |
| Author_xml | – sequence: 1 givenname: Thomas surname: Blank fullname: Blank, Thomas organization: Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, D-37075 Goettingen, Germany – sequence: 2 givenname: Ingrid surname: Nijholt fullname: Nijholt, Ingrid – sequence: 3 givenname: Min-Jeong surname: Kye fullname: Kye, Min-Jeong – sequence: 4 givenname: Jelena surname: Radulovic fullname: Radulovic, Jelena – sequence: 5 givenname: Joachim surname: Spiess fullname: Spiess, Joachim |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12883553$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Aging - genetics Aging - metabolism Animals Calcium ions Gene Expression Regulation - physiology Hippocampus - metabolism Long-term potentiation Long-Term Potentiation - physiology Memory Disorders - genetics Memory Disorders - metabolism Mice Physiological aspects Potassium channels Potassium Channels - biosynthesis Potassium Channels - genetics Potassium Channels, Calcium-Activated Small-Conductance Calcium-Activated Potassium Channels |
| Title | Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits |
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