The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists

A series of (perfluoroalkyl)imidazoles have been prepared and are potent angiotensin II antagonists. One of these compounds, DuP 532, 4-pentafluoroethyl-2-propyl-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylic acid, is a selective antagonist of angiotensin II which causes a mark...

Full description

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 3; no. 5; pp. 895 - 898
Main Authors Carini, David J., Chiu, Andrew T., Wong, Pancras C., Johnson, Alexander L., Wexler, Ruth R., Timmermans, Pieter B.M.W.M.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.05.1993
Online AccessGet full text

Cover

More Information
Summary:A series of (perfluoroalkyl)imidazoles have been prepared and are potent angiotensin II antagonists. One of these compounds, DuP 532, 4-pentafluoroethyl-2-propyl-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylic acid, is a selective antagonist of angiotensin II which causes a marked and long-lasting drop in blood pressure when administered orally to a renal hypertensive rat. A series of (perfluoroalkyl)imidazoles have been prepared and are potent angiotensin II antagonists. One of these compounds, DuP 532, is a selective antagonist of angiotensin II which causes a marked and long-lasting drop in blood pressure when administered orally to a renal hypertensive rat.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80688-5