Pathophysiology of bronchial smooth muscle remodelling in asthma

• Published in: The European respiratory journal Vol. 36; no. 5; pp. 1174 - 1184
• Main Authors: Bara, I., Ozier, A., Tunon de Lara, J-M., Marthan, R., Berger, P.
• Format: Journal Article
• Language: English
• Published: Leeds Maney 01.11.2010
• Subjects: Animals; Asthma - pathology; Asthma - physiopathology; Biological and medical sciences; Bronchi - pathology; Bronchi - physiopathology; Cell Division - physiology; Chronic obstructive pulmonary disease, asthma; Extracellular Matrix - pathology; Extracellular Matrix - physiology; Humans; Medical sciences; Muscle, Smooth - pathology; Muscle, Smooth - physiopathology; Pneumology; Lung disease; Pathophysiology; Respiratory disease; Bronchus; remodelling; Bronchus disease; Smooth muscle; Obstructive pulmonary disease; Proliferation; Asthma; Pneumology; bronchi

Whereas the role of bronchial smooth muscle remains controversial in healthy subjects its role is well established in asthmatics. Bronchial smooth muscle contraction induces airway narrowing. The smooth muscle also contributes to bronchial inflammation by secreting a range of inflammatory mediators,...