Nerve-derived trophic factors and DNA elements controlling expression of genes encoding synaptic proteins in skeletal muscle fibers
The neuromuscular junction represents an excellent model system for studying various critical issues in neurobiology at the molecular, cellular, and physiological levels. Our understanding of the basic events underlying synpase formation, maintenance, and plasticity has progressed considerably over...
Saved in:
Published in | Canadian journal of applied physiology Vol. 23; no. 4; p. 366 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.08.1998
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | The neuromuscular junction represents an excellent model system for studying various critical issues in neurobiology at the molecular, cellular, and physiological levels. Our understanding of the basic events underlying synpase formation, maintenance, and plasticity has progressed considerably over the last few years primarily because of the numerous studies that have focused on this synapse and used sophisticated recombinant DNA technology. Recent data indicate that myonuclei located in the vicinity of the postsynaptic membrane are in a differential state of transcription compared to nuclei of the extrasynaptic sarcoplasm. Thus, renewal of postsynaptic membrane proteins appears to occur via a mechanism involving the local transcriptional activation of genes encoding these specialized proteins and extracellular cues originating from motoneurons. Such interaction between presynaptic nerve terminals and the postsynaptic sarcoplasm indicates that the entire signal transduction pathway is compartmentalized at the level of the neuromuscular junction. Expression of these genes appears less coregulated than originally anticipated, indicating that maintenance of the postsynaptic membrane requires the contribution of multiple extracellular signals, which ultimately urge target transcription factors to distinct DNA regulatory elements via various second messenger systems. |
---|---|
AbstractList | The neuromuscular junction represents an excellent model system for studying various critical issues in neurobiology at the molecular, cellular, and physiological levels. Our understanding of the basic events underlying synpase formation, maintenance, and plasticity has progressed considerably over the last few years primarily because of the numerous studies that have focused on this synapse and used sophisticated recombinant DNA technology. Recent data indicate that myonuclei located in the vicinity of the postsynaptic membrane are in a differential state of transcription compared to nuclei of the extrasynaptic sarcoplasm. Thus, renewal of postsynaptic membrane proteins appears to occur via a mechanism involving the local transcriptional activation of genes encoding these specialized proteins and extracellular cues originating from motoneurons. Such interaction between presynaptic nerve terminals and the postsynaptic sarcoplasm indicates that the entire signal transduction pathway is compartmentalized at the level of the neuromuscular junction. Expression of these genes appears less coregulated than originally anticipated, indicating that maintenance of the postsynaptic membrane requires the contribution of multiple extracellular signals, which ultimately urge target transcription factors to distinct DNA regulatory elements via various second messenger systems. |
Author | Boudreau-Larivière, C Mankal, F A Adatia, F A Angus, L Chan, R Y Wu, J Lunde, J A Krupa, A M Jasmin, B J Gramolini, A O |
Author_xml | – sequence: 1 givenname: B J surname: Jasmin fullname: Jasmin, B J organization: Faculty of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa, ON, Canada – sequence: 2 givenname: A O surname: Gramolini fullname: Gramolini, A O – sequence: 3 givenname: F A surname: Adatia fullname: Adatia, F A – sequence: 4 givenname: L surname: Angus fullname: Angus, L – sequence: 5 givenname: C surname: Boudreau-Larivière fullname: Boudreau-Larivière, C – sequence: 6 givenname: R Y surname: Chan fullname: Chan, R Y – sequence: 7 givenname: A M surname: Krupa fullname: Krupa, A M – sequence: 8 givenname: J A surname: Lunde fullname: Lunde, J A – sequence: 9 givenname: F A surname: Mankal fullname: Mankal, F A – sequence: 10 givenname: J surname: Wu fullname: Wu, J |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9677433$$D View this record in MEDLINE/PubMed |
BookMark | eNotkM1OAjEYRRuDQUDjE5j0BUbb6dCfJUFRE4IbXZNO-xWqM-2kHYisfXHHyOre5J6cxZ2iUYgBELql5J5Sph72ShakpBdoQucVK0pB5WjohPNCSFpdoWnOn4RQSaQao7HiQlSMTdDPBtIRCgvJH8HiPsVu7w122vQxZayDxY-bBYYGWgh9xiaGgWkaH3YYvrsEOfsYcHR4BwEyhmCi_RvzKeiuH1Rdij34kLEPOH8Nol43uD1k0wB2voaUr9Gl002Gm3PO0Mfq6X35Uqzfnl-Xi3VhmGB9QbUQxoBTisuaOKbmFXAjjHZCK-KktNwR5-rSiMqVUEtuOedEA-HzmleynKG7f293qFuw2y75VqfT9nxG-QsDRWUk |
CitedBy_id | crossref_primary_10_1002_bies_10205 crossref_primary_10_3390_ijms19020556 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1139/h98-021 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Recreation & Sports |
EISSN | 1543-2718 |
ExternalDocumentID | 9677433 |
Genre | Comparative Study Review Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | -~X .GJ 0R~ 0WA 186 2QV 36B 4.4 53G 5RP AAFWJ AAIKC AAJWC AAMNW AAWTL AAYJJ ACGFS AEULQ ALMA_UNASSIGNED_HOLDINGS CGR CUY CVF D8U DXH EBS ECM EIF EJD HZ~ IAO IEA IHR INH INR ITC NMEPN NPM NRXXU O9- OHT RRCRK RRP U5U UKR XFK YYQ ZGI |
ID | FETCH-LOGICAL-c373t-1a77ccef9968b0f3954e6c7caf7a90f88d6f0ffb2c74f2eb86d6660ae065b6482 |
ISSN | 1066-7814 |
IngestDate | Fri Feb 23 02:55:18 EST 2024 |
IsPeerReviewed | false |
IsScholarly | false |
Issue | 4 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c373t-1a77ccef9968b0f3954e6c7caf7a90f88d6f0ffb2c74f2eb86d6660ae065b6482 |
PMID | 9677433 |
ParticipantIDs | pubmed_primary_9677433 |
PublicationCentury | 1900 |
PublicationDate | 1998-08-01 |
PublicationDateYYYYMMDD | 1998-08-01 |
PublicationDate_xml | – month: 08 year: 1998 text: 1998-08-01 day: 01 |
PublicationDecade | 1990 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Canadian journal of applied physiology |
PublicationTitleAlternate | Can J Appl Physiol |
PublicationYear | 1998 |
SSID | ssj0018089 |
Score | 1.2859275 |
SecondaryResourceType | review_article |
Snippet | The neuromuscular junction represents an excellent model system for studying various critical issues in neurobiology at the molecular, cellular, and... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 366 |
SubjectTerms | Cell Nucleus - metabolism DNA - genetics Gene Expression Regulation Humans Motor Neurons - physiology Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Nerve Growth Factors - physiology Nerve Tissue Proteins - genetics Neuromuscular Junction - metabolism Neuronal Plasticity - physiology Receptors, Presynaptic - physiology Second Messenger Systems - physiology Signal Transduction - physiology Synapses - metabolism Synapses - physiology Synaptic Membranes - metabolism Synaptic Membranes - ultrastructure Transcription, Genetic |
Title | Nerve-derived trophic factors and DNA elements controlling expression of genes encoding synaptic proteins in skeletal muscle fibers |
URI | https://www.ncbi.nlm.nih.gov/pubmed/9677433 |
Volume | 23 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBablkIupUkb-kjDHEovi1qvJVv2cSlNQyDbQxPILUiylCxlvUu8W9pe84vyDzN6eO2kD9JevIsFsuz5GM2M5psh5A0zNpPCSqqEVpRXaUZLKxjFrVEZK0eaGUdOPprkByf88DQ7HQyue1lLq6V6p3_-llfyP1LFeyhXx5L9B8muJ8Ub-B_li1eUMF7vJeOJS1ekFT7qG9qNy8v54mKq1y10fJLxZDw0IUO8adPSPQHdfI8ZsN5cPHcab-hqWnqOS_OjlgtXydVXcZiGXPPmK07kqJOzVYPrGFqXa9L0jdt1pYNeOQoZrVwfQbkVwj-UzSw2i-_Opj5dyplrIzQNOutzl06Ar-zt3P0u-jquz1dNx5yoOjJf0cYugrpFg4e6olthN4oqmDOaiqiVo44OnOSIRd5TuCz0bPl1I2CujuqFe2RgYPfgsJh5PJQ5mr6hCsdfB-_U444jG2RDFE6lTlx4KB5bFYnvubh-rcDSdot5H5eySR7FCe74Md6eOX5CHkdHBMYBVVtkYOptst15EfAWvvjjpKfk6hbOIOIMIs4AcQaIM2hxBj2cQYczmFvwOIMWZ9DiDFqcwbSGFmcQcAYBZ8_Iyf7H4w8HNDbvoJoJtqQjKYTWxqI_XajEsjLjJtdCSytkmdiiqHKbWKtSLbhNjSryCj3pRBq0iVXOi3SHPKjntXlOoFJGcmW4NKbkXOOvFWrEs9SKqkxk9YLshC95tggVWs7iJ375p4FXZLOD4y55aFEhmNdoXS7VnpfoDTkxggw |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nerve-derived+trophic+factors+and+DNA+elements+controlling+expression+of+genes+encoding+synaptic+proteins+in+skeletal+muscle+fibers&rft.jtitle=Canadian+journal+of+applied+physiology&rft.au=Jasmin%2C+B+J&rft.au=Gramolini%2C+A+O&rft.au=Adatia%2C+F+A&rft.au=Angus%2C+L&rft.date=1998-08-01&rft.issn=1066-7814&rft.eissn=1543-2718&rft.volume=23&rft.issue=4&rft.spage=366&rft_id=info:doi/10.1139%2Fh98-021&rft_id=info%3Apmid%2F9677433&rft_id=info%3Apmid%2F9677433&rft.externalDocID=9677433 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1066-7814&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1066-7814&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1066-7814&client=summon |