Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation

• Published in: The European respiratory journal Vol. 35; no. 6; pp. 1264 - 1272
• Main Authors: McKeon, D. J., Cadwallader, K. A., Idris, S., Cowburn, A. S., Pasteur, M. C., Barker, H., Haworth, C. S., Bilton, D., Chilvers, E. R., Condliffe, A. M.
• Format: Journal Article
• Language: English
• Published: Leeds Maney 01.06.2010
• Subjects: Adult; Biological and medical sciences; Blotting, Western; Cystic Fibrosis - immunology; Cystic Fibrosis - metabolism; Cystic Fibrosis Transmembrane Conductance Regulator - genetics; Cystic Fibrosis Transmembrane Conductance Regulator - metabolism; Errors of metabolism; Female; Gene Expression - immunology; Humans; Male; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; NADPH Oxidases - metabolism; Neutrophils - immunology; Neutrophils - metabolism; Phosphoproteins - metabolism; Pneumology; Pneumonia - immunology; Pneumonia - metabolism; Reactive Oxygen Species - immunology; Reactive Oxygen Species - metabolism; Respiratory Burst - immunology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Oxygen; Enzyme; Respiratory disease; Granulocyte; Oxidase; Metabolic diseases; Cystic fibrosis; Inflammation; Genetic disease; NADPH oxidase; Digestive diseases; Oxidoreductases; Neutrophil; Cystic fibrosis transmembrane conductance regulator; Pancreatic disease; Pneumology

Previous studies have identified abnormalities in the oxidative responses of the neutrophil in cystic fibrosis (CF), but it is unclear whether such changes relate to loss of membrane cystic fibrosis transmembrane conductance regulator (CFTR) or to the inflammatory environment present in this disease...