Hepatic UDP-Glucuronosyltransferase Is Responsible for Eslicarbazepine Glucuronidation - Loureiro, Ana I.; Fernandes-Lopes, Carlos; Bonifácio, Maria J.; Wright, Lyndon C.; Soares-da-Silva, Patricio (Drug metabolism and disposition, 2011)
Keywords: Animals; Anticonvulsants - metabolism; Biological and medical sciences; Dibenzazepines - metabolism; Escherichia coli - metabolism; Glucuronidase - metabolism; Glucuronides - metabolism; Glucuronosyltransferase - metabolism; Humans; Kinetics; Liver - enzymology; Liver - metabolism; Medical sciences; Mice; Microsomes, Liver - enzymology; Microsomes, Liver - metabolism; Pharmacology. Drug treatments; Serum Albumin, Bovine - metabolism; Trifluoperazine - metabolism; Uridine Diphosphate Glucuronic Acid - metabolism; BSA; UGT; UDPGA; HLM; ISTD; OXC; MS/MS; HPLC; ESL; MLM; UDP-glucuronosyltransferase; Digestive system; Enzyme; Transferases; Liver; Glycosyltransferases; Glucuronic acid conjugation; Anticonvulsant; Eslicarbazepine; Metabolism; Hexosyltransferases; Sodium channel blocker; Pharmacokinetics