Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin

• Published in: The FASEB journal Vol. 31; no. 10; p. 4265
• Main Authors: Hsu, Jinn-Yuan, Chang, Jang-Yang, Chang, Kwang-Yu, Chang, Wen-Chang, Chen, Ben-Kuen
• Format: Journal Article
• Language: English
• Published: United States 01.10.2017
• Subjects: Carcinoma, Squamous Cell - metabolism; Cell Line, Tumor; Cell Movement - drug effects; Epidermal Growth Factor - metabolism; Epidermal Growth Factor - pharmacology; ErbB Receptors - metabolism; Fibronectins - metabolism; Head and Neck Neoplasms - metabolism; Humans; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Neoplasm Invasiveness - pathology; Protein-Serine-Threonine Kinases - metabolism; Squamous Cell Carcinoma of Head and Neck; Transcriptional Activation - drug effects; Up-Regulation - drug effects; MMP; EGF; HNSCC; PDK1

Epidermal growth factor receptor (EGFR) activation is a major cause of metastasis in such cancers as head and neck squamous cell carcinoma (HNSCC); however, whether the metabolic enzyme, pyruvate dehydrogenase kinase 1 (PDK1), mediates EGF-enhanced HNSCC metastasis remains unclear. Of interest, we f...