In Vivo Self‐Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization

• Published in: Angewandte Chemie International Edition Vol. 60; no. 47; pp. 25128 - 25134
• Main Authors: Guo, Ruo‐Chen, Zhang, Xue‐Hao, Fan, Peng‐Sheng, Song, Ben‐Li, Li, Zhi‐Xiang, Duan, Zhong‐Yu, Qiao, Zeng‐Ying, Wang, Hao
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 15.11.2021
• Edition: International ed. in English
• Subjects: Alkaline phosphatase; Alkaline Phosphatase - metabolism; Assembly; cancer; Cell Membrane - chemistry; Cell Membrane - metabolism; Cell membranes; Drug delivery; Humans; Internalization; Lipids; Membranes; peptide; Peptides; Peptides - chemistry; Peptides - isolation & purification; Peptides - metabolism; Phase separation; Protein Conformation; self-assembly; self-assembly; peptide; phase separation; cancer; drug delivery

Therapeutic peptides have been widely concerned, but their efficacy is limited by the inability to penetrate cell membranes, which is a key bottleneck in peptide drugs delivery. Herein, an in vivo self‐assembly strategy is developed to induce phase separation of cell membrane that improves the pepti...