Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy

• Published in: Angewandte Chemie International Edition Vol. 63; no. 13; pp. e202318539 - n/a
• Main Authors: Yan, Xiao, Li, Ke, Xie, Tian‐Qiu, Jin, Xiao‐Kang, Zhang, Cheng, Li, Qian‐Ru, Feng, Jun, Liu, Chuan‐Jun, Zhang, Xian‐Zheng
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 22.03.2024
• Edition: International ed. in English
• Subjects: Bioorthogonal chemistry; Cancer; Casualties; Chemotherapy; Click chemistry; Gold; Gold nanoparticle; Nanoparticles; Photothermal therapy; Prodrugs; Sensitizing; Synergistic therapy; Tumors; Photothermal therapy; Click chemistry; Bioorthogonal chemistry; Gold nanoparticle; Synergistic therapy

Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) has attracted great interest due to its high spatiotemporal controllability and noninvasiveness. Due to the trade‐off betwee...