Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 20; no. 48; pp. e2403679 - n/a
• Main Authors: Wei, Yun‐Jie, Chen, Heng, Zhou, Zi‐Wen, Liu, Chun‐Xiu, Cai, Chun‐Xian, Li, Jing, Yu, Xiao‐Qi, Zhang, Ji, Liu, Yan‐Hong, Wang, Na
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.11.2024
• Subjects: Accumulation; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibacterial; Antiinfectives and antibacterials; Bacterial infections; Bioreactors; Blood circulation; Blood vessels; Catalase; Chitosan; Chitosan - chemistry; Chlorogenic acid; Diabetes; diabetic wound healing; Dissolved oxygen; Genipin; Hydrogels; Hydrogels - chemistry; Hydrogen peroxide; Hypoxia; Infections; Iridoids - chemistry; Iridoids - pharmacology; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Metal-Organic Frameworks - pharmacology; Mice; nanozymes; Oxidation resistance; Oxygen - chemistry; Oxygenation; reactive oxygen species; Reactive Oxygen Species - metabolism; Scavenging; Wound healing; Wound Healing - drug effects; nanozymes; antibacterial; hydrogels; diabetic wound healing; reactive oxygen species

Diabetic wounds tend to develop into nonhealing wounds associated with the complex inflammatory microenvironment of uncontrollable bacterial infection, reactive oxygen species (ROS) accumulation, and chronic hypoxia. Damaged blood vessels hinder metabolic circulation, aggravating hypoxia, and ROS ac...