Regio‐ and Enantioselective γ‐Allylic Alkylation of In Situ‐Generated Free Dienolates via Scandium/Iridium Dual Catalysis

• Published in: Angewandte Chemie International Edition Vol. 61; no. 19; pp. e202117079 - n/a
• Main Authors: Zhang, Jian, Yang, Wu‐Lin, Zheng, Hanliang, Wang, Yi, Deng, Wei‐Ping
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 02.05.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alkylation; Allylation; Asymmetric Synthesis; Bimetals; Catalysis; Chemistry; Chemistry, Multidisciplinary; Computer applications; Density functional theory; Dienolates; Dual Catalysis; Enantiomers; Iridium; Physical Sciences; Reaction mechanisms; Scandium; Science & Technology; Stereoisomerism; Dual Catalysis; N-HETEROCYCLIC CARBENE; ASYMMETRIC-SYNTHESIS; SYNERGISTIC IRIDIUM; ENANTIO; ALPHA-AMINO-ACIDS; SUBSTITUTION-REACTIONS; Dienolates; DIASTEREO; Allylation; ALCOHOLS; REARRANGEMENT; Asymmetric Synthesis; Iridium

An unprecedented asymmetric γ‐allylic alkylation of free dienolates via Sc/Ir dual catalysis is reported, which affords a range of synthetically versatile γ‐allylic crotonaldehydes in high efficiency with excellent chemo‐, regio‐, and enantioselectivities. The dienolates bearing no essential auxilia...