Macrocyclic‐Amphiphile‐Based Self‐Assembled Nanoparticles for Ratiometric Delivery of Therapeutic Combinations to Tumors

• Published in: Advanced materials (Weinheim) Vol. 33; no. 12; pp. e2007719 - n/a
• Main Authors: Zhang, Zhanzhan, Yue, Yu‐Xin, Xu, Lina, Wang, Ying, Geng, Wen‐Chao, Li, Juan‐Juan, Kong, Xiang‐lei, Zhao, Xinzhi, Zheng, Yadan, Zhao, Yu, Shi, Linqi, Guo, Dong‐Sheng, Liu, Yang
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2021
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Cancer; Cell Line, Tumor; combination chemotherapy; Controlled release; Doxorubicin - chemistry; Doxorubicin - pharmacology; Doxorubicin - therapeutic use; Drug Carriers - chemistry; Drug Liberation; Drugs; Humans; hypoxia; macrocyclic amphiphiles; Macrocyclic Compounds - chemistry; Materials science; Mice; molecular recognition; Nanoparticles; Nanoparticles - chemistry; Neoplasms - drug therapy; ratiometric delivery; Tumors; hypoxia; molecular recognition; macrocyclic amphiphiles; ratiometric delivery; combination chemotherapy

Combination chemotherapy refers to the use of multiple drugs to treat cancer. In this therapy, the optimal ratio of the drugs is essential to achieve drug synergism and the desired therapeutic effects. However, most delivery strategies are unable to precisely control the ratio of the drugs during th...