Synthesis of α‐Quaternary β‐Lactams via Copper‐Catalyzed Enantioconvergent Radical C(sp3)−C(sp2) Cross‐Coupling with Organoboronate Esters

• Published in: Angewandte Chemie International Edition Vol. 62; no. 2; pp. e202214709 - n/a
• Main Authors: Wang, Fu‐Li, Liu, Lin, Yang, Chang‐Jiang, Luan, Cheng, Yang, Jing, Chen, Ji‐Jun, Gu, Qiang‐Shuai, Li, Zhong‐Liang, Liu, Xin‐Yuan
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 09.01.2023; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Asymmetric Catalysis; beta-Lactams; Catalysis; Catalysts; Chemical reactions; Chemistry; Chemistry, Multidisciplinary; Construction; Copper; Copper - chemistry; Cross coupling; Electrons; Esters; Physical Sciences; Radical Chemistry; Science & Technology; β-Lactam; TRANSITION-METAL CATALYSIS; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; beta-Lactam; Radical Chemistry; SUBSTITUTION-REACTIONS; ARYLBORONIC ACIDS; ALKYL-HALIDES; Asymmetric Catalysis; TRANSMETALATION; Cross-Coupling; Copper; DERIVATIVES; ACCESS; CYCLIZATION; β-Lactam

The copper‐catalyzed enantioconvergent radical C(sp3)−C(sp2) cross‐coupling of tertiary α‐bromo‐β‐lactams with organoboronate esters could provide the synthetically valuable α‐quaternary β‐lactams. The challenge arises mainly from the construction of sterically congested quaternary stereocenters bet...