Enhancing the Release Efficiency of a Molecular Chemotherapeutic Prodrug by Photodynamic Therapy

• Published in: Angewandte Chemie International Edition Vol. 61; no. 33; pp. e202206169 - n/a
• Main Authors: Yuan, Jie, Zhou, Qian‐Hui, Xu, Shuai, Zuo, Qing‐Ping, Li, Wei, Zhang, Xing‐Xing, Ren, Tian‐Bing, Yuan, Lin, Zhang, Xiao‐Bing
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 15.08.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Bioavailability; Chemistry; Chemistry, Multidisciplinary; Chemotherapy; Drug delivery; Drug development; Drugs; Fluorescent Probes; Hypoxia; Hypoxia-Activated Prodrugs; Irradiation; Light irradiation; Mitochondria; Photoacoustic Imaging; Photodynamic Therapy; Physical Sciences; Prodrugs; Radiation; Science & Technology; Side effects; Tumors; Tumours; NANOPARTICLES; DYES; Tumours; Fluorescent Probes; Hypoxia-Activated Prodrugs; MITOCHONDRIA; Photodynamic Therapy; Photoacoustic Imaging; fluorescent probe; hypoxia-activated prodrug; photoacoustic imaging; photodynamic therapy; tumour

Tumor‐specific, hypoxia‐activated prodrugs have been developed to alleviate the side effects of chemotherapy drugs. However, the release efficiency of hypoxia‐activated prodrugs is restricted by the degree of tumor hypoxia, which further leads to poor cancer treatment effects. On the other hand, oxy...