Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

• Published in: Advanced materials (Weinheim) Vol. 36; no. 24; pp. e2312939 - n/a
• Main Authors: Fatima, Mahak, Almalki, Waleed H., Khan, Tasneem, Sahebkar, Amirhossein, Kesharwani, Prashant
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.06.2024
• Subjects: Animals; biomedical applications; cancer; Chronic conditions; Drug Carriers - chemistry; drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Humans; Medical research; Nanoparticles - chemistry; Pharmacology; smart nanomaterials; Stimuli; stimuli‐responsive; smart nanomaterials; cancer; drug delivery; biomedical applications; stimuli‐responsive
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.202312939

The quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location, has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli‐reactive nanosystems in biomedicine and outlines future development prospects. Stimuli responsive nanoparticles have gained immense popularity in detection and treatment of several ailments. The article provides a brief overview of available endogenous and exogenous stimuli. Further section discusses their applications in combatting major life‐threatening diseases. Major challenges and future prospects of stimuli responsive nanoparticles are also discussed.