Copper‐Catalyzed Enantioselective Dehydro‐Diels–Alder Reaction: Atom‐Economical Synthesis of Axially Chiral Carbazoles

• Published in: Angewandte Chemie International Edition Vol. 63; no. 51; pp. e202411709 - n/a
• Main Authors: Chen, Hua‐Hong, Chen, Yang‐Bo, Gao, Jun‐Zhe, Ye, Long‐Wu, Zhou, Bo
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 16.12.2024; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Aromatic compounds; Asymmetric Catalysis; Axial Chirality; Carbazole; Carbazoles; Catalysis; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Copper; DDA Reaction; Diels-Alder reactions; Enantiomers; Heterocycles; Noble metals; Physical Sciences; Science & Technology; Ynamides; DDA Reaction; Heterocycles; STYRENES; INSERTION; REAGENTS; Ynamides; RESOLUTION; ATROPISOMERS; CYCLOADDITION; Asymmetric Catalysis; Axial Chirality; ACCESS; ALKALOIDS; DIYNES

The dehydro‐Diels–Alder (DDA) reaction is a powerful method for the construction of aromatic compounds. However, the enantioselective DDA reaction has been rarely developed, probably due to the competitive thermal reaction. Herein, we report a copper‐catalyzed enantioselective DDA reaction through v...