Artificial Super Neutrophils for Inflammation Targeting and HClO Generation against Tumors and Infections
Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial “super neutrophils” are proposed with excellent in...
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| Published in | Advanced materials (Weinheim) Vol. 31; no. 19; pp. e1901179 - n/a |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Wiley Subscription Services, Inc
01.05.2019
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| Online Access | Get full text |
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| Abstract | Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial “super neutrophils” are proposed with excellent inflammation targeting and hypochlorous acid (HClO) generation characteristics for targeting and eliminating malignant tumor cells and pathogens. The “super neutrophils” are fabricated by embedding glucose oxidase (GOx) and chloroperoxidase (CPO) into zeolitic imidazolate framework‐8 (ZIF‐8) for HClO generation via enzymatic cascades, and then encapsulating them with the neutrophil membrane (NM) for inflammation targeting. In vitro and in vivo results indicate that these artificial “super neutrophils” can generate seven times higher reactive HClO than the natural neutrophils for eradicating tumors and infections. The “super neutrophils” demonstrated here with easy fabrication and good neutrophil‐mimicking property exhibit great potential for biomedical applications.
Artificial “super neutrophils” (GCZM) are designed to simulate the inflammation targeting and HClO generation functions of natural neutrophils. GCZM can accumulate in inflammation sites and exhibit high efficacy to generate highly toxic HClO for complete tumor and pathogen elimination. |
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| AbstractList | Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial "super neutrophils" are proposed with excellent inflammation targeting and hypochlorous acid (HClO) generation characteristics for targeting and eliminating malignant tumor cells and pathogens. The "super neutrophils" are fabricated by embedding glucose oxidase (GOx) and chloroperoxidase (CPO) into zeolitic imidazolate framework-8 (ZIF-8) for HClO generation via enzymatic cascades, and then encapsulating them with the neutrophil membrane (NM) for inflammation targeting. In vitro and in vivo results indicate that these artificial "super neutrophils" can generate seven times higher reactive HClO than the natural neutrophils for eradicating tumors and infections. The "super neutrophils" demonstrated here with easy fabrication and good neutrophil-mimicking property exhibit great potential for biomedical applications.Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial "super neutrophils" are proposed with excellent inflammation targeting and hypochlorous acid (HClO) generation characteristics for targeting and eliminating malignant tumor cells and pathogens. The "super neutrophils" are fabricated by embedding glucose oxidase (GOx) and chloroperoxidase (CPO) into zeolitic imidazolate framework-8 (ZIF-8) for HClO generation via enzymatic cascades, and then encapsulating them with the neutrophil membrane (NM) for inflammation targeting. In vitro and in vivo results indicate that these artificial "super neutrophils" can generate seven times higher reactive HClO than the natural neutrophils for eradicating tumors and infections. The "super neutrophils" demonstrated here with easy fabrication and good neutrophil-mimicking property exhibit great potential for biomedical applications. Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial “super neutrophils” are proposed with excellent inflammation targeting and hypochlorous acid (HClO) generation characteristics for targeting and eliminating malignant tumor cells and pathogens. The “super neutrophils” are fabricated by embedding glucose oxidase (GOx) and chloroperoxidase (CPO) into zeolitic imidazolate framework‐8 (ZIF‐8) for HClO generation via enzymatic cascades, and then encapsulating them with the neutrophil membrane (NM) for inflammation targeting. In vitro and in vivo results indicate that these artificial “super neutrophils” can generate seven times higher reactive HClO than the natural neutrophils for eradicating tumors and infections. The “super neutrophils” demonstrated here with easy fabrication and good neutrophil‐mimicking property exhibit great potential for biomedical applications. Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial “super neutrophils” are proposed with excellent inflammation targeting and hypochlorous acid (HClO) generation characteristics for targeting and eliminating malignant tumor cells and pathogens. The “super neutrophils” are fabricated by embedding glucose oxidase (GOx) and chloroperoxidase (CPO) into zeolitic imidazolate framework‐8 (ZIF‐8) for HClO generation via enzymatic cascades, and then encapsulating them with the neutrophil membrane (NM) for inflammation targeting. In vitro and in vivo results indicate that these artificial “super neutrophils” can generate seven times higher reactive HClO than the natural neutrophils for eradicating tumors and infections. The “super neutrophils” demonstrated here with easy fabrication and good neutrophil‐mimicking property exhibit great potential for biomedical applications. Artificial “super neutrophils” (GCZM) are designed to simulate the inflammation targeting and HClO generation functions of natural neutrophils. GCZM can accumulate in inflammation sites and exhibit high efficacy to generate highly toxic HClO for complete tumor and pathogen elimination. |
| Author | Zhang, Lu Liu, Chuan‐Jun Wu, Wei Zhuang, Ze‐Nan Zhang, Xian‐Zheng Zhang, Chi Li, Run‐Qing Song, Wen Gao, Fan |
| Author_xml | – sequence: 1 givenname: Chi surname: Zhang fullname: Zhang, Chi organization: Wuhan University – sequence: 2 givenname: Lu surname: Zhang fullname: Zhang, Lu organization: Wuhan University – sequence: 3 givenname: Wei surname: Wu fullname: Wu, Wei organization: Wuhan University – sequence: 4 givenname: Fan surname: Gao fullname: Gao, Fan organization: Wuhan University – sequence: 5 givenname: Run‐Qing surname: Li fullname: Li, Run‐Qing organization: Wuhan University – sequence: 6 givenname: Wen surname: Song fullname: Song, Wen organization: Wuhan University – sequence: 7 givenname: Ze‐Nan surname: Zhuang fullname: Zhuang, Ze‐Nan organization: Wuhan University – sequence: 8 givenname: Chuan‐Jun surname: Liu fullname: Liu, Chuan‐Jun organization: Wuhan University – sequence: 9 givenname: Xian‐Zheng orcidid: 0000-0001-6242-6005 surname: Zhang fullname: Zhang, Xian‐Zheng email: xz-zhang@whu.edu.cn organization: Wuhan University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30924234$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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| Keywords | biomimetic materials antitumor neutrophils HClO antibiosis |
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| SubjectTerms | antibiosis antitumor Biomedical materials biomimetic materials Cascades Glucose oxidase HClO Immune system Infections Inflammation Leukocytes Materials science Metal-organic frameworks Neutrophils Pathogens Tumors Zeolites |
| Title | Artificial Super Neutrophils for Inflammation Targeting and HClO Generation against Tumors and Infections |
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