Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors

• Published in: Advanced materials (Weinheim) Vol. 34; no. 15; pp. e2109969 - n/a
• Main Authors: Sun, Lei, Zhou, Jing‐e, Luo, Tengshuo, Wang, Jing, Kang, Liqing, Wang, Yeying, Luo, Shenggen, Wang, Zhehao, Zhou, Ziyu, Zhu, Jiaxi, Yu, Jiahui, Yu, Lei, Yan, Zhiqiang
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.04.2022
• Subjects: Animals; Biomedical materials; Cell Line, Tumor; Diagnosis; Fluorocarbons; Liposomes; Liposomes - therapeutic use; malignant tumors; Materials science; Medical imaging; Mice; Multilayers; multimode imaging; nanoengineered neutrophils; Nanoengineering; Neoplasms - diagnostic imaging; Neoplasms - drug therapy; Neutrophils; Oxygen; Perfluorocarbons; Reactive Oxygen Species - therapeutic use; sonodynamic therapy; sonosensitizers; Tumors; Ultrasonic imaging; Ultrasonic Therapy - methods; multimode imaging; malignant tumors; sonodynamic therapy; sonosensitizers; nanoengineered neutrophils

The rapid evolution of cell‐based theranostics has attracted extensive attention due to their unique advantages in biomedical applications. However, the inherent functions of cells alone cannot meet the needs of malignant tumor treatment. Thus endowing original cells with new characteristics to gene...