Synthetic K+ Channels Constructed by Rebuilding the Core Modules of Natural K+ Channels in an Artificial System
Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+ channels by rebuilding the core modules of natural K+ channels in artificial systems. All the channels displayed high selectivity for K+ ove...
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| Published in | Angewandte Chemie International Edition Vol. 62; no. 8; pp. e202217859 - n/a |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Wiley Subscription Services, Inc
13.02.2023
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| Edition | International ed. in English |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+ channels by rebuilding the core modules of natural K+ channels in artificial systems. All the channels displayed high selectivity for K+ over Na+ and exhibited a selectivity sequence of K+≈Rb+ during the transport process, which is highly consistent with the cation permeability characteristics of natural K+ channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K+, disrupting the cellular K+ homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K+ channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K+ channels can be mimicked in synthetic channels.
Rebuilding the core modules of natural K+ channels in an artificial system has led to a biomimetic K+ channel. This channel possesses similar structural features as the natural version, which enables it to replicate the transport behavior and biological function of natural K+ channels. |
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| AbstractList | Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+ channels by rebuilding the core modules of natural K+ channels in artificial systems. All the channels displayed high selectivity for K+ over Na+ and exhibited a selectivity sequence of K+≈Rb+ during the transport process, which is highly consistent with the cation permeability characteristics of natural K+ channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K+, disrupting the cellular K+ homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K+ channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K+ channels can be mimicked in synthetic channels.
Rebuilding the core modules of natural K+ channels in an artificial system has led to a biomimetic K+ channel. This channel possesses similar structural features as the natural version, which enables it to replicate the transport behavior and biological function of natural K+ channels. Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+ channels by rebuilding the core modules of natural K+ channels in artificial systems. All the channels displayed high selectivity for K+ over Na+ and exhibited a selectivity sequence of K+≈Rb+ during the transport process, which is highly consistent with the cation permeability characteristics of natural K+ channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K+, disrupting the cellular K+ homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K+ channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K+ channels can be mimicked in synthetic channels. Different types of natural K + channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K + channels by rebuilding the core modules of natural K + channels in artificial systems. All the channels displayed high selectivity for K + over Na + and exhibited a selectivity sequence of K + ≈Rb + during the transport process, which is highly consistent with the cation permeability characteristics of natural K + channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K + , disrupting the cellular K + homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K + channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K + channels can be mimicked in synthetic channels. Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+ channels by rebuilding the core modules of natural K+ channels in artificial systems. All the channels displayed high selectivity for K+ over Na+ and exhibited a selectivity sequence of K+ ≈Rb+ during the transport process, which is highly consistent with the cation permeability characteristics of natural K+ channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K+ , disrupting the cellular K+ homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K+ channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K+ channels can be mimicked in synthetic channels.Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+ channels by rebuilding the core modules of natural K+ channels in artificial systems. All the channels displayed high selectivity for K+ over Na+ and exhibited a selectivity sequence of K+ ≈Rb+ during the transport process, which is highly consistent with the cation permeability characteristics of natural K+ channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K+ , disrupting the cellular K+ homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K+ channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K+ channels can be mimicked in synthetic channels. Different types of natural K channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K channels by rebuilding the core modules of natural K channels in artificial systems. All the channels displayed high selectivity for K over Na and exhibited a selectivity sequence of K ≈Rb during the transport process, which is highly consistent with the cation permeability characteristics of natural K channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K , disrupting the cellular K homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K channels can be mimicked in synthetic channels. |
| Author | Guo, Jingjing Pei, Yan Xin, Pengyang Xu, Linqi Bi, Jingjing Dong, Wenpei Chen, Chang‐Po Zhang, Shouwei Mao, Linlin |
| Author_xml | – sequence: 1 givenname: Pengyang orcidid: 0000-0003-4947-7953 surname: Xin fullname: Xin, Pengyang email: pyxin27@163.com organization: Henan Normal University – sequence: 2 givenname: Linqi surname: Xu fullname: Xu, Linqi organization: Henan Normal University – sequence: 3 givenname: Wenpei surname: Dong fullname: Dong, Wenpei organization: Henan Normal University – sequence: 4 givenname: Linlin surname: Mao fullname: Mao, Linlin organization: Henan Normal University – sequence: 5 givenname: Jingjing orcidid: 0000-0002-4632-4364 surname: Guo fullname: Guo, Jingjing email: jguo@ipm.edu.mo organization: Macao Polytechnic University – sequence: 6 givenname: Jingjing surname: Bi fullname: Bi, Jingjing organization: Henan Normal University – sequence: 7 givenname: Shouwei surname: Zhang fullname: Zhang, Shouwei organization: Henan Normal University – sequence: 8 givenname: Yan surname: Pei fullname: Pei, Yan organization: Henan Normal University – sequence: 9 givenname: Chang‐Po surname: Chen fullname: Chen, Chang‐Po email: changpochen@yahoo.com organization: Henan Normal University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36583482$$D View this record in MEDLINE/PubMed |
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| Keywords | Transmembrane Transport Cyclodextrins Ion Channels Potassium Supramolecular Chemistry |
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| Snippet | Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+... Different types of natural K + channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K... Different types of natural K channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K... |
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| StartPage | e202217859 |
| SubjectTerms | Apoptosis Biological Transport Cations Cell membranes Channels Cyclodextrins Homeostasis Ion Channels Modules Permeability Potassium Potassium - metabolism Rebuilding Rubidium Selectivity Sodium Supramolecular Chemistry Transmembrane Transport Transport processes |
| Title | Synthetic K+ Channels Constructed by Rebuilding the Core Modules of Natural K+ Channels in an Artificial System |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fanie.202217859 https://www.ncbi.nlm.nih.gov/pubmed/36583482 https://www.proquest.com/docview/2774022960 https://www.proquest.com/docview/2759959708 |
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