Simultaneous Photoactivation of cGAS‐STING Pathway and Pyroptosis by Platinum(II) Triphenylamine Complexes for Cancer Immunotherapy

• Published in: Angewandte Chemie International Edition Vol. 61; no. 43; pp. e202210988 - n/a
• Main Authors: Ling, Yu‐Yi, Xia, Xiao‐Yu, Hao, Liang, Wang, Wen‐Jin, Zhang, Hang, Liu, Liu‐Yi, Liu, Wenting, Li, Zhi‐Yuan, Tan, Cai‐Ping, Mao, Zong‐Wan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 24.10.2022
• Edition: International ed. in English
• Subjects: Antiviral Agents - pharmacology; Cancer immunotherapy; cGAS-STING; DNA - metabolism; DNA Binding; DNA damage; Immune response; Immune system; Immunotherapy; Interferon; Interferons - pharmacology; Irradiation; Light effects; Light irradiation; Membrane Proteins - metabolism; Mitochondrial DNA; Neoplasms - therapy; Nucleotidyltransferases - metabolism; Photoactivation; Photoimmunotherapy; Platinum - pharmacology; PtII Complexes; Pyroptosis; Radiation; Radiation damage; Signal Transduction; Stimulators; Photoimmunotherapy; Pyroptosis; PtII Complexes; cGAS-STING; DNA Binding

Activation of the cyclic GMP‐AMP synthase‐stimulator of the interferon gene (cGAS‐STING) pathway is a potent anticancer immunotherapeutic strategy, and the induction of pyroptosis is a feasible way to stimulate the anticancer immune responses. Herein, two PtII complexes (Pt1 and Pt2) were designed a...