A New 1,5‐Dihydroxy‐4‐methoxyisoquinoline from Scolopendra subspinipes mutilans

• Published in: Chemistry & biodiversity Vol. 14; no. 6
• Main Authors: Guo, Ya‐Ru, Wu, Peng‐Xiang, Xu, Han‐Mei, Qi, Wei‐Yan
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.06.2017
• Subjects: Animals; Anticancer properties; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Arthropods - chemistry; Cancer; Carcinoma, Squamous Cell - drug therapy; Cell adhesion & migration; Cell Line, Tumor; Cell migration; Cell Movement - drug effects; Cytotoxic activities; Cytotoxicity; Endothelial cells; Epithelial cells; Esophageal Neoplasms - drug therapy; Esophageal Squamous Cell Carcinoma; Esophagus; Humans; Inhibitory Concentration 50; Isoquinoline alkaloid; Isoquinolines - isolation & purification; Isoquinolines - pharmacology; Migration; Scolopendra subspinipes mutilans; Structure-Activity Relationship; Toxicity; Tumors; Umbilical vein; Isoquinoline alkaloid; Scolopendra subspinipes mutilans; Migration; Cytotoxic activities; Cancer

A new isoquinoline, 1,5‐dihydroxy‐4‐methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC50 values ranging from 13 to 26 μm against five esophageal squamous cancer cells whereas low cytotoxicity against normal hum...