A New 1,5‐Dihydroxy‐4‐methoxyisoquinoline from Scolopendra subspinipes mutilans
A new isoquinoline, 1,5‐dihydroxy‐4‐methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC50 values ranging from 13 to 26 μm against five esophageal squamous cancer cells whereas low cytotoxicity against normal hum...
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| Published in | Chemistry & biodiversity Vol. 14; no. 6 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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| Abstract | A new isoquinoline, 1,5‐dihydroxy‐4‐methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC50 values ranging from 13 to 26 μm against five esophageal squamous cancer cells whereas low cytotoxicity against normal human esophageal epithelial cells. Isoquinoline ring oxidized at C(1), C(4), and C(5) can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate > 50% at 13 μm) on cell migration in human umbilical vein endothelial cells. This article mainly studies the structure and activity of 1, and more modification of 1 as a potential anticancer agent. |
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| AbstractList | A new isoquinoline, 1,5-dihydroxy-4-methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC
values ranging from 13 to 26 μm against five esophageal squamous cancer cells whereas low cytotoxicity against normal human esophageal epithelial cells. Isoquinoline ring oxidized at C(1), C(4), and C(5) can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate > 50% at 13 μm) on cell migration in human umbilical vein endothelial cells. This article mainly studies the structure and activity of 1, and more modification of 1 as a potential anticancer agent. A new isoquinoline, 1,5-dihydroxy-4-methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC50 values ranging from 13 to 26 μm against five esophageal squamous cancer cells whereas low cytotoxicity against normal human esophageal epithelial cells. Isoquinoline ring oxidized at C(1), C(4), and C(5) can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate > 50% at 13 μm) on cell migration in human umbilical vein endothelial cells. This article mainly studies the structure and activity of 1, and more modification of 1 as a potential anticancer agent. A new isoquinoline, 1,5‐dihydroxy‐4‐methoxyisoquinoline ( 1 ), was obtained from Scolopendra subspinipes mutilans . Compound 1 showed moderate cytotoxicity on tumour cells with IC 50 values ranging from 13 to 26 μ m against five esophageal squamous cancer cells whereas low cytotoxicity against normal human esophageal epithelial cells. Isoquinoline ring oxidized at C(1), C(4), and C(5) can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate > 50% at 13 μ m ) on cell migration in human umbilical vein endothelial cells. This article mainly studies the structure and activity of 1 , and more modification of 1 as a potential anticancer agent. A new isoquinoline, 1,5‐dihydroxy‐4‐methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC50 values ranging from 13 to 26 μm against five esophageal squamous cancer cells whereas low cytotoxicity against normal human esophageal epithelial cells. Isoquinoline ring oxidized at C(1), C(4), and C(5) can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate > 50% at 13 μm) on cell migration in human umbilical vein endothelial cells. This article mainly studies the structure and activity of 1, and more modification of 1 as a potential anticancer agent. A new isoquinoline, 1,5-dihydroxy-4-methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC50 values ranging from 13 to 26 µm against five esophageal squamous cancer cells whereas low cytotoxicity against normal human esophageal epithelial cells. Isoquinoline ring oxidized at C(1), C(4), and C(5) can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate > 50% at 13 µm) on cell migration in human umbilical vein endothelial cells. This article mainly studies the structure and activity of 1, and more modification of 1 as a potential anticancer agent. |
| Author | Wu, Peng‐Xiang Guo, Ya‐Ru Xu, Han‐Mei Qi, Wei‐Yan |
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| Keywords | Isoquinoline alkaloid Scolopendra subspinipes mutilans Migration Cytotoxic activities Cancer |
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| Snippet | A new isoquinoline, 1,5‐dihydroxy‐4‐methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on... A new isoquinoline, 1,5-dihydroxy-4-methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on... A new isoquinoline, 1,5‐dihydroxy‐4‐methoxyisoquinoline ( 1 ), was obtained from Scolopendra subspinipes mutilans . Compound 1 showed moderate cytotoxicity on... |
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| SubjectTerms | Animals Anticancer properties Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Arthropods - chemistry Cancer Carcinoma, Squamous Cell - drug therapy Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement - drug effects Cytotoxic activities Cytotoxicity Endothelial cells Epithelial cells Esophageal Neoplasms - drug therapy Esophageal Squamous Cell Carcinoma Esophagus Humans Inhibitory Concentration 50 Isoquinoline alkaloid Isoquinolines - isolation & purification Isoquinolines - pharmacology Migration Scolopendra subspinipes mutilans Structure-Activity Relationship Toxicity Tumors Umbilical vein |
| Title | A New 1,5‐Dihydroxy‐4‐methoxyisoquinoline from Scolopendra subspinipes mutilans |
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