Lipid‐Embedded Molecular Dynamics Simulation Model for Exploring the Reverse Prostaglandin D2 Agonism of CT‐133 towards CRTH2 in the Treatment of Type‐2 Inflammation Dependent Diseases

• Published in: Chemistry & biodiversity Vol. 17; no. 3; pp. e1900548 - n/a
• Main Authors: Issahaku, Abdul Rashid, Agoni, Clement, Kumi, Ransford O., Olotu, Fisayo A., Soliman, Mahmoud E. S.
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.03.2020
• Subjects: Allergies; Arrestin; Binding; chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2); Chemotaxis; Cigarette smoke; Computer applications; Computer simulation; CT-133; Diseases; Helper cells; Homology; Inflammation; Inhibitors; Lipids; Lymphocytes T; Medical treatment; Molecular dynamics; molecular dynamics simulation; PGD2 antagonists; Prostaglandin D2; reverse agonism; Signal transduction; Software; Stability; PGD2 antagonists; reverse agonism; CT-133; chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2); prostaglandin d2; molecular dynamics simulation

Chemoattractant receptor‐homologous molecule expressed on Th2 cells (CRTH2) has been involved in several inflammation dependent diseases by mediating the chemotaxis of pro‐inflammatory cells in response to allergy and other responses through PGD2 ligation. This CRTH2‐PGD2 signaling pathway has becom...