Phytochemical Profiling and Compound Isolation of Cissus rhombifolia Vahl. Leaves Aqueous Methanolic Extract with the Evaluation of Its Anti‐Inflammatory Effect Using Lipopolysaccharide‐Induced Inflammation in RAW 264.7 Cells
The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti‐inflammatory effect. Cissus rhombifolia Vahl. leaves’ anti‐inflammatory activities and phytoconstituents are poorly characterized. In this study, 38 constituents were tentatively characterized in Cissus...
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Published in | Chemistry & biodiversity Vol. 20; no. 7; pp. e202300307 - n/a |
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Language | English |
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Abstract | The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti‐inflammatory effect. Cissus rhombifolia Vahl. leaves’ anti‐inflammatory activities and phytoconstituents are poorly characterized. In this study, 38 constituents were tentatively characterized in Cissus rhombifolia Vahl. leaves’ aqueous methanolic extract (CRLE) using high‐performance liquid chromatography combined with mass spectrometry (HPLC/MS) and Proton Nuclear Magnetic Resonance (1H‐NMR). Myricetin, β‐amyrin, and alliospiroside A, were isolated from CRLE using column chromatography. The anti‐inflammatory effect of CRLE and its isolated compounds were studied in lipopolysaccharide (LPS)‐induced RAW 264.7 cells. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT assay) was used to assess how CRLE and its isolated compounds affected cell viability. Further, its effects on the production of intracellular NO, and inflammatory cytokines cyclooxygenase‐2 (COX‐2), tumor necrosis factor alpha (TNF‐α), and interleukin 6 (IL‐6) were assessed by the Griess test, and cytokine enzyme‐linked immunosorbent assays, respectively. CRLE and its isolated compounds, myricetin, β‐amyrin, and alliospiroside A decreased the NO production. Western blotting was performed to assess the protein expression levels of the inflammatory cytokines inducible nitric oxide synthase (iNOS). Alliospiroside A downregulated IL‐6, TNF‐α, and COX‐2 and inhibited the expression of iNOS. CRLE and its compounds represent effective alternative candidate to treat inflammatory diseases. |
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AbstractList | Abstract
The inflammatory disorders represent a serious health issue. Certain
Cissus
species possess anti‐inflammatory effect.
Cissus rhombifolia
Vahl. leaves’ anti‐inflammatory activities and phytoconstituents are poorly characterized. In this study, 38 constituents were tentatively characterized in
Cissus rhombifolia
Vahl. leaves’ aqueous methanolic extract (CRLE) using high‐performance liquid chromatography combined with mass spectrometry (HPLC/MS) and Proton Nuclear Magnetic Resonance (
1
H‐NMR). Myricetin, β‐amyrin, and alliospiroside A, were isolated from CRLE using column chromatography. The anti‐inflammatory effect of CRLE and its isolated compounds were studied in lipopolysaccharide (LPS)‐induced RAW 264.7 cells. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT assay) was used to assess how CRLE and its isolated compounds affected cell viability. Further, its effects on the production of intracellular NO, and inflammatory cytokines cyclooxygenase‐2 (COX‐2), tumor necrosis factor alpha (TNF‐α), and interleukin 6 (IL‐6) were assessed by the Griess test, and cytokine enzyme‐linked immunosorbent assays, respectively. CRLE and its isolated compounds, myricetin, β‐amyrin, and alliospiroside A decreased the NO production. Western blotting was performed to assess the protein expression levels of the inflammatory cytokines inducible nitric oxide synthase (iNOS). Alliospiroside A downregulated IL‐6, TNF‐α, and COX‐2 and inhibited the expression of iNOS. CRLE and its compounds represent effective alternative candidate to treat inflammatory diseases. The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti‐inflammatory effect. Cissus rhombifolia Vahl. leaves’ anti‐inflammatory activities and phytoconstituents are poorly characterized. In this study, 38 constituents were tentatively characterized in Cissus rhombifolia Vahl. leaves’ aqueous methanolic extract (CRLE) using high‐performance liquid chromatography combined with mass spectrometry (HPLC/MS) and Proton Nuclear Magnetic Resonance (1H‐NMR). Myricetin, β‐amyrin, and alliospiroside A, were isolated from CRLE using column chromatography. The anti‐inflammatory effect of CRLE and its isolated compounds were studied in lipopolysaccharide (LPS)‐induced RAW 264.7 cells. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT assay) was used to assess how CRLE and its isolated compounds affected cell viability. Further, its effects on the production of intracellular NO, and inflammatory cytokines cyclooxygenase‐2 (COX‐2), tumor necrosis factor alpha (TNF‐α), and interleukin 6 (IL‐6) were assessed by the Griess test, and cytokine enzyme‐linked immunosorbent assays, respectively. CRLE and its isolated compounds, myricetin, β‐amyrin, and alliospiroside A decreased the NO production. Western blotting was performed to assess the protein expression levels of the inflammatory cytokines inducible nitric oxide synthase (iNOS). Alliospiroside A downregulated IL‐6, TNF‐α, and COX‐2 and inhibited the expression of iNOS. CRLE and its compounds represent effective alternative candidate to treat inflammatory diseases. The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti-inflammatory effect. Cissus rhombifolia Vahl. leaves' anti-inflammatory activities and phytoconstituents are poorly characterized. In this study, 38 constituents were tentatively characterized in Cissus rhombifolia Vahl. leaves' aqueous methanolic extract (CRLE) using high-performance liquid chromatography combined with mass spectrometry (HPLC/MS) and Proton Nuclear Magnetic Resonance ( H-NMR). Myricetin, β-amyrin, and alliospiroside A, were isolated from CRLE using column chromatography. The anti-inflammatory effect of CRLE and its isolated compounds were studied in lipopolysaccharide (LPS)-induced RAW 264.7 cells. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay) was used to assess how CRLE and its isolated compounds affected cell viability. Further, its effects on the production of intracellular NO, and inflammatory cytokines cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) were assessed by the Griess test, and cytokine enzyme-linked immunosorbent assays, respectively. CRLE and its isolated compounds, myricetin, β-amyrin, and alliospiroside A decreased the NO production. Western blotting was performed to assess the protein expression levels of the inflammatory cytokines inducible nitric oxide synthase (iNOS). Alliospiroside A downregulated IL-6, TNF-α, and COX-2 and inhibited the expression of iNOS. CRLE and its compounds represent effective alternative candidate to treat inflammatory diseases. |
Author | Mounier, Marwa M. Raslan, Mona A. |
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Keywords | alliospiroside A RAW 264.7 macrophages inflammation Cissus rhombifolia phytochemistry |
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Snippet | The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti‐inflammatory effect. Cissus rhombifolia Vahl. leaves’... The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti-inflammatory effect. Cissus rhombifolia Vahl. leaves'... Abstract The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti‐inflammatory effect. Cissus rhombifolia Vahl. leaves’... |
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SubjectTerms | alliospiroside A Cell viability Chromatography Cissus rhombifolia Column chromatography Cytokines High performance liquid chromatography Immunoassays inflammation Inflammatory diseases Interleukin 6 Lipopolysaccharides Liquid chromatography Mass spectrometry Mass spectroscopy Nitric oxide Nitric-oxide synthase NMR Nuclear magnetic resonance phytochemistry Prostaglandin endoperoxide synthase RAW 264.7 macrophages Tumor necrosis factor-TNF Western blotting |
Title | Phytochemical Profiling and Compound Isolation of Cissus rhombifolia Vahl. Leaves Aqueous Methanolic Extract with the Evaluation of Its Anti‐Inflammatory Effect Using Lipopolysaccharide‐Induced Inflammation in RAW 264.7 Cells |
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