Lymph‐Node‐Targeted Drug Delivery for Effective Immunomodulation to Prolong the Long‐Term Survival After Heart Transplantation

• Published in: Advanced materials (Weinheim) Vol. 35; no. 16; pp. e2207227 - n/a
• Main Authors: Che, Yan‐Jia, Ren, Xiao‐He, Wang, Zhi‐Wei, Wu, Qi, Xing, Kai, Zhang, Min, Xu, Chang, Han, Di, Yuan, Shun, Zheng, Si‐Hao, Chen, Yuan‐Yang, Liao, Xin‐Ru, Shi, Feng, Zhong, Xiao‐Han, Cai, Xin, Cheng, Si‐Xue
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.04.2023
• Subjects: Animals; aptamers; Calcium carbonate; Drug Delivery Systems; Fingolimod Hydrochloride - pharmacology; Heart; Heart Transplantation; Heparin; Humans; hybrid nanoparticles; immune regulation; Immune Tolerance; Immunity; Immunomodulation; Immunosuppression; Immunosuppressive Agents - pharmacology; Lymph Nodes; Lymphocytes; lymph‐node‐targeted delivery; Materials science; Mice; Side effects; Survival; Xenotransplantation; lymph-node-targeted delivery; heart transplantation; aptamers; immune regulation; hybrid nanoparticles

The chronic rejection responses and side effects of the systematic administration of immunosuppressants are the main obstacles to heart allograft and patient survival. The development of xenotransplantation also urgently requires more efficient immune regulation strategies. Herein, it is demonstrate...