Regulating Twisted Skeleton to Construct Organ‐Specific Perylene for Intensive Cancer Chemotherapy

• Published in: Angewandte Chemie International Edition Vol. 60; no. 29; pp. 16215 - 16223
• Main Authors: Liu, Zhonghua, Wang, Xuejuan, Chen, Qing, Ma, Feiyan, Huang, Yongwei, Gao, Yijian, Deng, Qingyuan, Qiao, Zeng‐Ying, Xing, Xiaoyi, Zhu, Jianling, Lu, Feng, Wang, Hao
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 12.07.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Adenosine triphosphate; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; ATP; Autophagy; Calcium; Cell Line, Tumor; Cell Proliferation - drug effects; Chemistry; Chemistry, Multidisciplinary; Chemotherapy; Drug development; Drug Screening Assays, Antitumor; Endoplasmic reticulum; fluorescence image; Humans; Hydrogen peroxide; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Metastases; Mice; Mitochondria; molecular mechanism; perylene; Perylene - analogs & derivatives; Perylene - chemistry; Perylene - pharmacology; Phagocytosis; Pharmaceuticals; Physical Sciences; Science & Technology; Side effects; twisted skeleton; Xenografts; CELLS; APOPTOSIS; fluorescence image; ER-STRESS; MITOCHONDRIA; MECHANISMS; chemotherapy; DELIVERY; perylene; LUNG-CANCER; molecular mechanism; IMPACT; twisted skeleton; AGENTS; PROBE

The systemic use of pharmaceutical drugs for cancer patients is a compromise between desirable therapy and side effects because of the intrinsic shortage of organ‐specific pharmaceutical drug. Design and construction of pharmaceutical drug to achieve the organ‐specific delivery is thus desperately d...