Profiling Auspicious Butyrylcholinesterase Inhibitory Activity of Two Herbal Molecules: Hyperforin and Hyuganin C

• Published in: Chemistry & biodiversity Vol. 16; no. 5; pp. e1900017 - n/a
• Main Authors: Orhan, Ilkay Erdogan, Senol Deniz, F. Sezer, Trædal‐Henden, Steinar, Cerón‐Carrasco, José P., den Haan, Helena, Peña‐García, Jorge, Pérez‐Sánchez, Horacio, Emerce, Esra, Skalicka‐Wozniak, Krystyna
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.05.2019
• Subjects: Alzheimer's disease; butyrylcholinesterase; Catalysis; Cholinergics; Cholinesterase; coumarin; Drug development; enzyme inhibition; Galantamine; Hepatotoxicity; Hydrophobicity; Inhibitors; Molecular docking; natural products; Neurodegenerative diseases; Residues; Therapy; natural products; butyrylcholinesterase; molecular docking; enzyme inhibition; coumarin

Cholinergic therapy based on cholinesterase (ChE) inhibitory drugs is the mainstay for the treatment of Alzheimer's disease. Therefore, an extensive research has been continuing for the discovery of drug candidates as inhibitors of acetyl‐ and butyrylcholinesterase. In this study, two natural m...