Cablinosides A and B, Two Glycosidic Phenylacetic Acid Derivatives from the Leaves of Pogostemon cablin

• Published in: Chemistry & biodiversity Vol. 16; no. 5; pp. e1900137 - n/a
• Main Authors: Huang, Xiao‐Jun, Li, Ping, Yin, Zhi‐Qi, Lu, Jin‐Jian, Lin, Li‐Gen, Wang, Ying, Ye, Wen‐Cai, Zhang, Qing‐Wen
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.05.2019
• Subjects: alpha-Glucosidases - chemistry; alpha-Glucosidases - metabolism; Cablinosides A and B; Cell Survival - drug effects; Circular Dichroism; Cytotoxicity; Glucosidase; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Hep G2 Cells; Humans; inhibitors; Inhibitory Concentration 50; Leaves; Magnetic Resonance Spectroscopy; Molecular Conformation; NMR; Nuclear magnetic resonance; Organic chemistry; patchouli, cytotoxicity; Phenylacetates - chemistry; Phenylacetates - isolation & purification; Phenylacetates - pharmacology; Phenylacetic acid; phytochemistry; Plant Leaves - chemistry; Plant Leaves - metabolism; Pogostemon - chemistry; Pogostemon - metabolism; Pogostemon cablin; Quantum chemistry; Stereoisomerism; structure elucidation; α-Glucosidase; inhibitors; patchouli, cytotoxicity; structure elucidation; Pogostemon cablin; Cablinosides A and B; phytochemistry

A pair of new glycosidic epimers, cablinosides A (1a) and B (1b) were isolated from the leaves of Pogostemon cablin. The structures with absolute configurations of 1a and 1b were elucidated by extensive NMR investigation, and quantum chemical CD calculations. The epimer mixture 1 showed moderate α‐g...