Ferroptosis‐Enhanced Cancer Immunity by a Ferrocene‐Appended Iridium(III) Diphosphine Complex

• Published in: Angewandte Chemie International Edition Vol. 61; no. 16; pp. e202115247 - n/a
• Main Authors: Wang, Wen‐Jin, Ling, Yu‐Yi, Zhong, Yan‐Mei, Li, Zhi‐Yuan, Tan, Cai‐Ping, Mao, Zong‐Wan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 11.04.2022
• Edition: International ed. in English
• Subjects: Apoptosis; Cancer; Cancer immunotherapy; Cell death; Fenton-like reaction; Ferrocene; Ferroptosis; Free radicals; Gene sequencing; Glutathione; Glutathione peroxidase; Humans; Hydroxyl radicals; Immunity; Immunogenicity; Immunotherapy; Iridium; Iridium - pharmacology; Iridium(III) complex; Lipid Peroxidation; Lipids; Lymphocytes; Lymphocytes T; Lysosomes; Metallocenes; Microenvironments; Neoplasms - pathology; Peroxidase; Peroxidation; Sequence analysis; Tumor Microenvironment; Fenton-like reaction; Ferroptosis; Immunotherapy; Iridium(III) complex; Ferrocene

Ferroptosis is a programmed cell death pathway discovered in recent years, and ferroptosis‐inducing agents have great potential as new antitumor candidates. Here, we report a IrIII complex (Ir1) containing a ferrocene‐modified diphosphine ligand that localizes in lysosomes. Under the acidic environm...