An Engineered Imine Reductase for Highly Diastereo‐ and Enantioselective Synthesis of β‐Branched Amines with Contiguous Stereocenters - Zhu, Zhen‐Yu; Shi, Min; Li, Chen‐Lin; Gao, Yun‐Fei; Shen, Xin‐Yuan; Ding, Xu‐Wei; Chen, Fei‐Fei; Xu, Jian‐He; Chen, Qi; Zheng, Gao‐Wei (Angewandte Chemie International Edition, 2024)
Keywords: Amination; Amines; Amines - chemistry; Amines - metabolism; Asymmetric synthesis; Asymmetry; Biocatalysis; Biological activity; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; dynamic kinetic resolution; Enantiomers; imine reductase; Imines - chemistry; Imines - metabolism; Ketones; Kinetics; Molecular Structure; Oxidoreductases - chemistry; Oxidoreductases - metabolism; Physical Sciences; Protein Engineering; Reductase; Reductases; Science & Technology; Stereoisomerism; Stereoselectivity; tofacitinib; ALCOHOLS; imine reductase; protein engineering; AMINATION; ASYMMETRIC-SYNTHESIS; HYDROGENATION; TRANSAMINASES; BIOCATALYST; DIRECTED EVOLUTION; biocatalysis; dynamic kinetic resolution; tofacitinib