Synthesis of Axially Chiral N‐Arylindoles via Atroposelective Cyclization of Ynamides Catalyzed by Chiral Brønsted Acids

• Published in: Angewandte Chemie International Edition Vol. 61; no. 20; pp. e202201436 - n/a
• Main Authors: Wang, Ze‐Shu, Zhu, Lu‐Jing, Li, Cui‐Ting, Liu, Bin‐Yang, Hong, Xin, Ye, Long‐Wu
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 09.05.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alkynes; Asymmetry; Axial Chirality; Brønsted Acids; Catalysis; Chemistry; Chemistry, Multidisciplinary; Chirality; Heterocycles; Organocatalysis; Physical Sciences; Science & Technology; Heterocycles; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; REACTIVITY; SULFONAMIDES; DEPROTECTION; Organocatalysis; INDOLES; Bronsted Acids; Axial Chirality; CONSTRUCTION; C-C; ACCESS; Alkynes; Brønsted Acids

In recent years, asymmetric catalysis of ynamides has attracted much attention, but these reactions mostly constructed central chirality, except for a few examples on the synthesis of axially chiral compounds which exclusively relied on noble‐metal catalysis. Herein, a facile access to axially chira...