Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 13; no. 33
• Main Authors: Ferreira, Mónica P. A., Ranjan, Sanjeev, Kinnunen, Sini, Correia, Alexandra, Talman, Virpi, Mäkilä, Ermei, Barrios‐Lopez, Brianda, Kemell, Marianna, Balasubramanian, Vimalkumar, Salonen, Jarno, Hirvonen, Jouni, Ruskoaho, Heikki, Airaksinen, Anu J., Santos, Hélder A.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2017
• Subjects: Autoradiography; Biocompatibility; Biodegradability; Computed tomography; drug delivery; Drug delivery systems; endocardium; Heart; Ischemia; ischemic heart; multifunctional nanoparticles; Myocardial infarction; Myocardium; Nanoparticles; Nanotechnology; Photon emission; Porous silicon; targeting; Toxicity; targeting; multifunctional nanoparticles; ischemic heart; drug delivery; endocardium

Ischemic heart disease is the leading cause of death globally. Severe myocardial ischemia results in a massive loss of myocytes and acute myocardial infarction, the endocardium being the most vulnerable region. At present, current therapeutic lines only ameliorate modestly the quality of life of the...