Longibrachiamide A, a 20‐Residue Peptaibol Isolated from Trichoderma longibrachiatum Rifai DMG‐3‐1‐1
Longibrachiamide A (1), a new 20‐residue peptaibol, along with three known ones (2–4), were isolated from the fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1, isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm, which was collected from coniferous forest of northeast China in our previo...
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| Published in | Chemistry & biodiversity Vol. 19; no. 6; pp. e202200286 - n/a |
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| Main Authors | , , , , , , , , , , , |
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| Abstract | Longibrachiamide A (1), a new 20‐residue peptaibol, along with three known ones (2–4), were isolated from the fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1, isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm, which was collected from coniferous forest of northeast China in our previous work. The structure of longibrachiamide A (1) was determined by its NMR and ESI‐MS/MS data, the absolute configuration of 1 was further determined by Marfey's analyses. And the complete NMR data of 2–4 were also reported for the first time. The similar CD spectra of 1–4 showed that they all had mixed 310‐/α‐helical conformations. Compounds 1–4 showed strong cytotoxicities against BV2, A549 and MCF‐7 cells, and also showed moderate inhibitory effects against the tested Gram‐positive bacteria, including MRSA T144 and VRE‐10. |
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| AbstractList | Longibrachiamide A (1), a new 20‐residue peptaibol, along with three known ones (2–4), were isolated from the fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1, isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm, which was collected from coniferous forest of northeast China in our previous work. The structure of longibrachiamide A (1) was determined by its NMR and ESI‐MS/MS data, the absolute configuration of 1 was further determined by Marfey's analyses. And the complete NMR data of 2–4 were also reported for the first time. The similar CD spectra of 1–4 showed that they all had mixed 310‐/α‐helical conformations. Compounds 1–4 showed strong cytotoxicities against BV2, A549 and MCF‐7 cells, and also showed moderate inhibitory effects against the tested Gram‐positive bacteria, including MRSA T144 and VRE‐10. Abstract Longibrachiamide A ( 1 ), a new 20‐residue peptaibol, along with three known ones ( 2 – 4 ), were isolated from the fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1, isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm, which was collected from coniferous forest of northeast China in our previous work. The structure of longibrachiamide A ( 1 ) was determined by its NMR and ESI‐MS/MS data, the absolute configuration of 1 was further determined by Marfey's analyses. And the complete NMR data of 2 – 4 were also reported for the first time. The similar CD spectra of 1 – 4 showed that they all had mixed 3 10 ‐/α‐helical conformations. Compounds 1 – 4 showed strong cytotoxicities against BV2, A549 and MCF‐7 cells, and also showed moderate inhibitory effects against the tested Gram‐positive bacteria, including MRSA T144 and VRE‐10. Longibrachiamide A (1), a new 20-residue peptaibol, along with three known ones (2-4), were isolated from the fungus Trichoderma longibrachiatum Rifai DMG-3-1-1, isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm, which was collected from coniferous forest of northeast China in our previous work. The structure of longibrachiamide A (1) was determined by its NMR and ESI-MS/MS data, the absolute configuration of 1 was further determined by Marfey's analyses. And the complete NMR data of 2-4 were also reported for the first time. The similar CD spectra of 1-4 showed that they all had mixed 3 -/α-helical conformations. Compounds 1-4 showed strong cytotoxicities against BV2, A549 and MCF-7 cells, and also showed moderate inhibitory effects against the tested Gram-positive bacteria, including MRSA T144 and VRE-10. |
| Author | Zhang, Guo‐Gang Xu, Rui Zhao, Xue Luo, Fu‐Yao Tang, Jing Zhang, Shu‐Hua Yang, Yu Zhu, Shuai‐Ming Zhang, Qin Li, Chang‐Wei Yue, Xian‐Lin Ma, Hao |
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| Keywords | antibacterial activity Trichoderma longibrachiatum longibrachiamide A peptaibol cytotoxicity |
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| Snippet | Longibrachiamide A (1), a new 20‐residue peptaibol, along with three known ones (2–4), were isolated from the fungus Trichoderma longibrachiatum Rifai... Longibrachiamide A (1), a new 20-residue peptaibol, along with three known ones (2-4), were isolated from the fungus Trichoderma longibrachiatum Rifai... Abstract Longibrachiamide A ( 1 ), a new 20‐residue peptaibol, along with three known ones ( 2 – 4 ), were isolated from the fungus Trichoderma longibrachiatum... |
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| SubjectTerms | Absolute configuration antibacterial activity Coniferous forests cytotoxicity Drug resistance Fungi longibrachiamide A NMR Nuclear magnetic resonance peptaibol Residues Trichoderma longibrachiatum |
| Title | Longibrachiamide A, a 20‐Residue Peptaibol Isolated from Trichoderma longibrachiatum Rifai DMG‐3‐1‐1 |
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