A General Approach to Design Dual Ratiometric Fluorescent and Photoacoustic Probes for Quantitatively Visualizing Tumor Hypoxia Levels In Vivo

• Published in: Angewandte Chemie International Edition Vol. 61; no. 7; pp. e202107076 - n/a
• Main Authors: Zhang, Shuping, Chen, Hua, Wang, Liping, Qin, Xue, Jiang, Bang‐Ping, Ji, Shi‐Chen, Shen, Xing‐Can, Liang, Hong
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 07.02.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Animals; Biomarkers; Breast cancer; Carbocyanines - chemical synthesis; Carbocyanines - chemistry; Cell Line, Tumor; Chemistry; Chemistry, Multidisciplinary; Drug Design; Dual ratiometric platform; Energy balance; Fluorescence; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fluorescent indicators; Hypoxia; In vivo imaging; Mammary Neoplasms, Experimental - diagnostic imaging; Medical imaging; Mice; Mice, Nude; Molecular Structure; Nitrobenzene; Nitrogen dioxide; Nitroreductase; Optical Imaging; Photoacoustic effect; Photoacoustic Techniques; Physical Sciences; Quantitative detection; Scaffolds; Science & Technology; Solid tumors; Sulfur; Thioxanthene; Tumor Hypoxia; Tumors; Xenografts; Xenotransplantation; Dual ratiometric platform; NANOPARTICLES; Nitroreductase; Tumor hypoxia; AGENTS; MICROSCOPY; Quantitative detection; In vivo imaging; NEAR-INFRARED FLUORESCENCE

Herein, we describe an energy balance strategy between fluorescence and photoacoustic effects by sulfur substitution to transform existing hemicyanine dyes (Cy) into optimized NIRF/PA dual ratiometric scaffolds. Based on this optimized scaffold, we reported the first dual‐ratio response of nitroredu...