Expeditious Access to Morphinans by Chemical Synthesis

• Published in: Angewandte Chemie International Edition Vol. 61; no. 27; pp. e202203186 - n/a
• Main Authors: White, Lorenzo V., Hu, Nan, He, Yu‐Tao, Banwell, Martin G., Lan, Ping
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 04.07.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alkaloids; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Climate change; Codeine; Medicine; Opiates; Palladium Catalysis; Photo-Redox Chemistry; Physical Sciences; Piperidine; Reaction time; Science & Technology; Supply chains; Total Synthesis; Work capacity; Total Synthesis; Alkaloids; ALKENES; Opiates; Palladium Catalysis; Photo-Redox Chemistry

Morphinans are essential medicines derived entirely from poppy supply chains rendered increasingly volatile by climate change. Here, we report a seven‐step, asymmetric chemical synthesis of (−)‐codeine from simple materials that requires a total combined reaction time of fewer than 24 hours. The eff...