Preclinical Anticancer Activity of an Electron‐Deficient Organoruthenium(II) Complex - Soldevila‐Barreda, Joan J.; Azmanova, Maria; Pitto‐Barry, Anaïs; Cooper, Patricia A.; Shnyder, Steven D.; Barry, Nicolas P. E. (ChemMedChem, 2020)
Keywords: Animals; Anticancer properties; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antitumor activity; Apoptosis - drug effects; Biotechnology; Cancer; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Cisplatin; Colon; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Cymene; Cytotoxicity; Dose-Response Relationship, Drug; Drug development; Drug Screening Assays, Antitumor; electron-deficient; Electrons; half-sandwich complexes; hollow fibre assay; Humans; In vivo methods and tests; in vivo evaluation; Lung cancer; metallodrugs; Mice; Molecular Structure; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - metabolism; Neoplasms, Experimental - pathology; Non-small cell lung carcinoma; Organoruthenium complexes; p53 Protein; Platinum; Reactive Oxygen Species - metabolism; Ruthenium; Ruthenium - chemistry; Ruthenium - pharmacology; Ruthenium compounds; Structure-Activity Relationship; Tumor cell lines; Xenografts; Xenotransplantation; in vivo evaluation; half-sandwich complexes; metallodrugs; hollow fibre assay; electron-deficient