Biosynthesis of Chuangxinmycin Featuring a Deubiquitinase‐like Sulfurtransferase

• Published in: Angewandte Chemie International Edition Vol. 60; no. 46; pp. 24418 - 24423
• Main Authors: Zhang, Xingwang, Xu, Xiaokun, You, Cai, Yang, Chaofan, Guo, Jiawei, Sang, Moli, Geng, Ce, Cheng, Fangyuan, Du, Lei, Shen, Yuemao, Wang, Sheng, Lan, Haidong, Yang, Fan, Li, Yuezhong, Tang, Ya‐Jie, Zhang, Youming, Bian, Xiaoying, Li, Shengying, Zhang, Wei
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 08.11.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Actinoplanes - genetics; Actinoplanes - metabolism; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; Antibiotics; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biosynthesis; Chemistry; Chemistry, Multidisciplinary; chuangxinmycin; C−S bond biosynthesis; deubiquitinase-like protein; Escherichia coli - chemistry; Escherichia coli - genetics; Escherichia coli - metabolism; Gene clusters; Humans; Indoles - analysis; Indoles - chemistry; Indoles - metabolism; Multigene Family; Physical Sciences; Proteins; Pyrococcus - enzymology; Pyrococcus - genetics; Science & Technology; Sulfur; Sulfur - metabolism; Sulfurtransferase; Sulfurtransferases - chemistry; Sulfurtransferases - genetics; Sulfurtransferases - metabolism; tRNA; Ubiquitin; Ubiquitination; Ubiquitins - genetics; Ubiquitins - metabolism; chuangxinmycin; ACTIVATION; POTENT; C-S bond biosynthesis; PROTEIN; sulfurtransferase; PATHWAY; CHEMISTRY; SULFUR; deubiquitinase-like protein; THIAMIN; sulfur metabolism; C−S bond biosynthesis

The knowledge on sulfur incorporation mechanism involved in sulfur‐containing molecule biosynthesis remains limited. Chuangxinmycin is a sulfur‐containing antibiotic with a unique thiopyrano[4,3,2‐cd]indole (TPI) skeleton and selective inhibitory activity against bacterial tryptophanyl‐tRNA syntheta...