Methyl‐Selective α‐Oxygenation of Tertiary Amines to Formamides by Employing Copper/Moderately Hindered Nitroxyl Radical (DMN‐AZADO or 1‐Me‐AZADO)

• Published in: Angewandte Chemie International Edition Vol. 58; no. 46; pp. 16651 - 16659
• Main Authors: Nakai, Satoru, Yatabe, Takafumi, Suzuki, Kosuke, Sasano, Yusuke, Iwabuchi, Yoshiharu, Hasegawa, Jun‐ya, Mizuno, Noritaka, Yamaguchi, Kazuya
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 11.11.2019
• Edition: International ed. in English
• Subjects: Amines; Catalysts; Chemical industry; Copper; formamides; methyl-selective α-oxygenation; nitroxyl radical; Oxidizing agents; Oxygen; Oxygenation; Reaction mechanisms; Regioselectivity; Substrates; tertiary amines; tertiary amines; copper; formamides; methyl-selective α-oxygenation; nitroxyl radical

Methyl‐selective α‐oxygenation of tertiary amines is a highly attractive approach for synthesizing formamides while preserving the amine substrate skeletons. Therefore, the development of efficient catalysts that can advance regioselective α‐oxygenation at the N‐methyl positions using molecular oxyg...