A Modular Approach for Diversity‐Oriented Synthesis of 1,3‐trans‐Disubstituted Tetrahydroisoquinolines: Seven‐Step Asymmetric Synthesis of Michellamines B and C

• Published in: Angewandte Chemie International Edition Vol. 61; no. 31; pp. e202205245 - n/a
• Main Authors: Bai, Miao, Jia, Shihu, Zhang, Jingyang, Cheng, Hong‐Gang, Cong, Hengjiang, Liu, Shanshan, Huang, Zhiqian, Huang, Yaoguo, Chen, Xiaoming, Zhou, Qianghui
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.08.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Acetylene; Alkaloids; Assembly; Asymmetric synthesis; Chemistry; Chemistry, Multidisciplinary; Diversity-Oriented Synthesis; Heterocycles; Iodides; Naphthylisoquinoline Alkaloids; Physical Sciences; Science & Technology; Synthesis; Tetrahydroisoquinoline; Tetrahydroisoquinolines; Total Synthesis; Heterocycles; Diversity-Oriented Synthesis; ALKYLATION; Naphthylisoquinoline Alkaloids; OXIDATIVE DIMERIZATION; HYDROAMINATION; Total Synthesis; FUNCTIONALIZATION; ACETOGENIC ISOQUINOLINE ALKALOIDS; KORUPENSAMINES-A-D; 1ST TOTAL-SYNTHESIS; 1,3-DISUBSTITUTED TETRAHYDROISOQUINOLINES; STEREOSELECTIVE-SYNTHESIS; Tetrahydroisoquinolines; total synthesis diversity-oriented synthesis heterocycles tetrahydroisoquinolines naphthylisoquinoline alkaloids

1,3‐trans‐Disubstituted tetrahydroisoquinoline (THIQ) is a common heterocyclic structural unit of naphthylisoquinoline alkaloids. The assembly of this structural unit is not trivial, which constitutes a substantial challenge in the total synthesis of naphthylisoquinoline alkaloids and related pharma...