Access to Alkenyl Cyclobutanols by Ni‐Catalyzed Regio‐ and Enantio‐Selective syn‐Hydrometalative 4‐exo‐trig Cyclization of Alkynones

• Published in: Angewandte Chemie International Edition Vol. 64; no. 3; pp. e202415164 - n/a
• Main Authors: Li, Xiao‐Lin, Deng, Jiang‐Lian, Long, Jian, Fu, Yi‐Fan, Zheng, Yu‐Qing, Liu, Wen‐Bo
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 15.01.2025; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: 4-exo-trig cyclization; Alkynes; bioisosteres; Carbonyl compounds; Carbonyls; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Cyclobutane; cyclobutanols; Enantiomers; functionalization of alkynes; nickel catalysis; Physical Sciences; Regioselectivity; Science & Technology; HYDROFUNCTIONALIZATION; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; LEWIS-ACID; CYCLOBUTENES; PHOTOCATALYSIS; nickel catalysis; 4-exo-trig cyclization; HYDROAMIDATION; functionalization of alkynes; 2+2 CYCLOADDITION; bioisosteres; LIGAND; cyclobutanols; DERIVATIVES

Enantioselective synthesis of (spiro)cyclobutane derivatives poses significant challenges yet holds promising applications for both synthetic and medicinal chemistry. We report here a nickel‐catalyzed asymmetric syn‐hydrometalative 4‐exo‐trig cyclization of 1,4‐alkynones to synthesize alkenyl cyclob...