Impact of met-haemoglobin and oxidative stress on endothelial function in patients with transfusion dependent β-thalassemia

• Published in: Scientific reports Vol. 14; no. 1; pp. 25328 - 9
• Main Authors: Rabie, Maha Abubakr Feissal, El Benhawy, Sanaa A., Masoud, Inas M., Arab, Amal R. R., Saleh, Sally A. M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/420; 692/699; 692/700; Adolescent; Adult; Anemia; beta-Thalassemia - blood; beta-Thalassemia - therapy; Biochemical analysis; Blood diseases; Blood Transfusion; Case-Control Studies; Creatinine; EASIX; Endothelial cells; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Female; Ferritin; Ferritins - blood; Free radicals; Hemoglobin; Hemoglobins - metabolism; Humanities and Social Sciences; Humans; Iron Overload - blood; Iron Overload - etiology; Male; Malondialdehyde; Malondialdehyde - blood; Met-Hb; multidisciplinary; Oxidative Stress; Science; Science (multidisciplinary); Splenectomy; Thalassemia; Transfusion; Transfusion depended β-thalassemia; Young Adult; Oxidative stress; Met-Hb; Transfusion depended β-thalassemia; EASIX; Malondialdehyde

Transfusion dependent β-thalassemia is a genetic blood disorder characterized by chronic anaemia. Blood transfusion is lifesaving but comes at a cost. Iron overload emerges as a prime culprit as a free radicals damage endothelial cells. Chronic anaemia further disrupts oxygen delivery, exacerbating...