Synthesis of W‐Phos Ligand and Its Application in the Copper‐Catalyzed Enantioselective Addition of Linear Grignard Reagents to Ketones

• Published in: Angewandte Chemie International Edition Vol. 61; no. 29; pp. e202204443 - n/a
• Main Authors: Luo, Wenjun, Zhang, Li‐Ming, Zhang, Zhan‐Ming, Zhang, Junliang
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 18.07.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alcohols; Asymmetric Catalysis; Asymmetry; Chemistry; Chemistry, Multidisciplinary; Copper; Enantiomers; Grignard Reagents; Ketones; Ligands; Physical Sciences; Reagents; Science & Technology; Ketones; Grignard Reagents; ALKYLATION; ASYMMETRIC ADDITION; CHIRAL TERTIARY ALCOHOLS; ALDEHYDES; 1,2-ADDITION; Alcohols; ORGANOBORON REAGENTS; ARYL ADDITIONS; Asymmetric Catalysis; CARBONYL; DIALKYLZINC REAGENTS; TITANIUM(IV) CATALYST; Copper

The asymmetric catalytic addition of linear Grignard reagents to ketones has been a long‐standing challenge in organic synthesis. Herein, a novel family of PNP ligands (W‐Phos) was designed and applied in copper‐catalyzed asymmetric addition of linear Grignard reagents to aryl alkyl ketones, allowin...