Copper‐Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp3)−H/C(sp)−H Cross‐Coupling with Rationally Designed Oxazoline‐Derived N,N,P(O)‐Ligands

• Published in: Angewandte Chemie International Edition Vol. 60; no. 51; pp. 26710 - 26717
• Main Authors: Liu, Lin, Guo, Kai‐Xin, Tian, Yu, Yang, Chang‐Jiang, Gu, Qiang‐Shuai, Li, Zhong‐Liang, Ye, Liu, Liu, Xin‐Yuan
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 13.12.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alkynes; alkynylation; anionic N,N,P(O)-ligands; Asymmetry; Chemical bonds; Chemistry; Chemistry, Multidisciplinary; Copper; copper catalysis; Cross coupling; Enantiomers; Ligands; oxidative cross-coupling; Physical Sciences; radical asymmetric chemistry; Radicals; Science & Technology; Selectivity; SUBSTITUTION; TETRAHYDROISOQUINOLINES; anionic N; ARYLATION; ALLYLIC ALKYLATION; alkynylation; H BOND FUNCTIONALIZATION; N; P(O)-ligands; copper catalysis; IODIDES; oxidative cross-coupling; LIGANDS; radical asymmetric chemistry; ARYL; anionic N,N,P(O)-ligands

The intermolecular asymmetric radical oxidative C(sp3)−C(sp) cross‐coupling of C(sp3)−H bonds with readily available terminal alkynes is a promising method to forge chiral C(sp3)−C(sp) bonds because of the high atom and step economy, but remains underexplored. Here, we report a copper‐catalyzed asym...