Antimicrobial Conjugated Oligoelectrolytes Containing Triphenylphosphonium Solubilizing Groups

• Published in: Chemistry : a European journal Vol. 29; no. 26; pp. e202203803 - n/a
• Main Authors: Chan, Samuel J. W., Zhang, Kaixi, Zhu, Ji‐Yu, Bazan, Guillermo C.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 08.05.2023; Wiley Subscription Services, Inc
• Subjects: Ammonium; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents; Antibiotics; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; Bacteria; Cell Membrane; Cell membranes; Chemistry; Chemistry, Multidisciplinary; conjugated oligoelectrolytes; Drug resistance; Lipophilic; Membrane permeability; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; mycobacteria; phosphonium; Physical Sciences; Science & Technology; Stilbene; structure−activity relationships; conjugated oligoelectrolytes; MEMBRANE PERTURBATION; DRUG DISCOVERY; MITOCHONDRIA; MECHANISMS; BACTERIAL; RESISTANT STAPHYLOCOCCUS-AUREUS; mycobacteria; MOLECULAR DESIGN; PEPTIDES; INHIBITION; antimicrobial agents; structure-activity relationships; CELL-ENVELOPE; phosphonium; structure−activity relationships

Conjugated oligoelectrolytes (COEs) are an emerging class of amphiphilic antimicrobial compounds with a modular molecular framework suitable for simple chemical derivatization. Here, a series of COE derivatives with a stilbene‐conjugated segment and triphenylphosphonium (TPP) pendant groups was desi...