Copper‐Catalyzed Enantioselective Doyle–Kirmse Reaction of Azide‐Ynamides via α‐Imino Copper Carbenes

• Published in: Angewandte Chemie International Edition Vol. 62; no. 10; pp. e202216923 - n/a
• Main Authors: Liu, Xin, Liu, Li‐Gao, Chen, Can‐Ming, Li, Xiao, Xu, Zhou, Lu, Xin, Zhou, Bo, Ye, Long‐Wu
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.03.2023; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: [2,3]-Sigmatropic Rearrangement; Asymmetric Catalysis; Asymmetry; Carbenes; Chemistry; Chemistry, Multidisciplinary; Copper; Divergence; Doyle-Kirmse Reaction; Enantiomers; Heterocycles; Indoles; Metal Carbene; Metals; Physical Sciences; Science & Technology; Heterocycles; Metal Carbene; SULFUR YLIDES; RAPID ACCESS; ALKYNES; ISOXAZOLES; 2; Asymmetric Catalysis; GOLD CARBENES; Doyle-Kirmse Reaction; 3]-Sigmatropic Rearrangement; GENERATION; ANTHRANILS; ALLYLIC SULFIDES; 2,3 SIGMATROPIC REARRANGEMENT; EFFICIENT; [2,3]-Sigmatropic Rearrangement

[2,3]‐Sigmatropic rearrangement reaction involving sulfonium ylide (Doyle–Kirmse reaction) generated from metal carbenes represents one of the powerful methods for the construction of C(sp3)−S and C−C bonds. Although significant advances have been achieved, the asymmetric versions via the generation...