In Situ Transformable Fibrillar Clusters Disrupt Intracellular Copper Metabolic Homeostasis by Comprehensive Blockage of Cuprous Ions Efflux

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 21; no. 1; pp. e2406802 - n/a
• Main Authors: Chen, Yichi, Wang, Yijun, Zhang, Ruotian, Wang, Fengyi, Lin, Xin, Wang, Tong, Zhang, Wenyuan, Deng, Fuan, Wu, Bolin, Shang, Haitao, Cheng, Wen, Zhang, Lu
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.01.2025
• Subjects: Animals; ATP7B protein; Cell Line, Tumor; Chemical synthesis; Clusters; colorectal cancer; Copper; Copper - chemistry; copper metabolic homeostasis; Copper-Transporting ATPases - metabolism; copper‐free cuproptosis; Efflux; Homeostasis; Homeostasis - drug effects; Humans; In vivo methods and tests; Ions; Membranes; Mice; Nanoparticles; Nanoparticles - chemistry; Proteins; Safety management; transformable fibrillar cluster; Tumors; colorectal cancer; copper‐free cuproptosis; transformable fibrillar cluster; ATP7B protein; copper metabolic homeostasis

Dysregulation of copper metabolism is intricately associated with the occurrence and therapeutic management of colorectal cancer. Previous studies have attempted to induce cuproptosis by delivering lethal doses of copper ions into tumor cells, often with systemic safety risks. In vivo, transformable...