Interaction of small molecules with polynucleotide repeats and frameshift site RNA
This mini‐review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA‐associated diseases or detecting target molecules. In the case of RNA‐associated disease treatment, the designed small molecules interact with RNA sites, forming adducts...
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| Published in | Archiv der Pharmazie (Weinheim) Vol. 352; no. 8; pp. e1900062 - n/a |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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01.08.2019
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| Abstract | This mini‐review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA‐associated diseases or detecting target molecules. In the case of RNA‐associated disease treatment, the designed small molecules interact with RNA sites, forming adducts and providing successful therapeutic strategies over oligonucleotides. On the other hand, synthetically designed RNA moieties (aptamers) interact with target molecules like toxins, drugs, hormones; these interactions are useful in the detection, quantification or separation of these target moieties.
Interaction of small organic heterocyclic compounds with different types of RNA is the subject of our review article. For example, N‐(3‐azidopropyl)‐4‐(3‐(6‐(4‐methylpiperazin‐1‐yl)‐1H,3′H‐[2,5′‐bibenzo[d]imidazol]‐2′‐yl)phenoxy)butanamide (Ht) is a parent compound, which was derivatized to achieve binding with RNA. The review article lists many different small molecules binding to different types of RNA. |
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| AbstractList | This mini-review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA-associated diseases or detecting target molecules. In the case of RNA-associated disease treatment, the designed small molecules interact with RNA sites, forming adducts and providing successful therapeutic strategies over oligonucleotides. On the other hand, synthetically designed RNA moieties (aptamers) interact with target molecules like toxins, drugs, hormones; these interactions are useful in the detection, quantification or separation of these target moieties. This mini‐review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA‐associated diseases or detecting target molecules. In the case of RNA‐associated disease treatment, the designed small molecules interact with RNA sites, forming adducts and providing successful therapeutic strategies over oligonucleotides. On the other hand, synthetically designed RNA moieties (aptamers) interact with target molecules like toxins, drugs, hormones; these interactions are useful in the detection, quantification or separation of these target moieties. This mini‐review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA‐associated diseases or detecting target molecules. In the case of RNA‐associated disease treatment, the designed small molecules interact with RNA sites, forming adducts and providing successful therapeutic strategies over oligonucleotides. On the other hand, synthetically designed RNA moieties (aptamers) interact with target molecules like toxins, drugs, hormones; these interactions are useful in the detection, quantification or separation of these target moieties. Interaction of small organic heterocyclic compounds with different types of RNA is the subject of our review article. For example, N‐(3‐azidopropyl)‐4‐(3‐(6‐(4‐methylpiperazin‐1‐yl)‐1H,3′H‐[2,5′‐bibenzo[d]imidazol]‐2′‐yl)phenoxy)butanamide (Ht) is a parent compound, which was derivatized to achieve binding with RNA. The review article lists many different small molecules binding to different types of RNA. This mini-review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA-associated diseases or detecting target molecules. In the case of RNA-associated disease treatment, the designed small molecules interact with RNA sites, forming adducts and providing successful therapeutic strategies over oligonucleotides. On the other hand, synthetically designed RNA moieties (aptamers) interact with target molecules like toxins, drugs, hormones; these interactions are useful in the detection, quantification or separation of these target moieties.This mini-review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA-associated diseases or detecting target molecules. In the case of RNA-associated disease treatment, the designed small molecules interact with RNA sites, forming adducts and providing successful therapeutic strategies over oligonucleotides. On the other hand, synthetically designed RNA moieties (aptamers) interact with target molecules like toxins, drugs, hormones; these interactions are useful in the detection, quantification or separation of these target moieties. |
| Author | Yousif, Mahmoud N. M. Nemr, Mohamed T. M. Barciszewski, Jan |
| Author_xml | – sequence: 1 givenname: Mohamed T. M. surname: Nemr fullname: Nemr, Mohamed T. M. organization: Cairo University – sequence: 2 givenname: Mahmoud N. M. surname: Yousif fullname: Yousif, Mahmoud N. M. organization: National Research Centre – sequence: 3 givenname: Jan orcidid: 0000-0001-7766-5594 surname: Barciszewski fullname: Barciszewski, Jan email: Jan.Barciszewski@ibch.poznan.pl organization: Adam Mickiewicz University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31169327$$D View this record in MEDLINE/PubMed |
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| Copyright | 2019 Deutsche Pharmazeutische Gesellschaft 2019 Deutsche Pharmazeutische Gesellschaft. 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
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| Keywords | RNA RNA-associated diseases FTD FXTAS ALS interaction AIDS DM1 aptamers small molecules |
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| SubjectTerms | AIDS ALS aptamers Aptamers, Nucleotide - chemical synthesis Aptamers, Nucleotide - chemistry DM1 FTD FXTAS Hormones - analysis interaction Pharmaceutical Preparations - analysis Polynucleotides - chemistry RNA RNA - chemistry RNA‐associated diseases Small Molecule Libraries - chemistry small molecules Toxins, Biological - analysis |
| Title | Interaction of small molecules with polynucleotide repeats and frameshift site RNA |
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