Mitochondria‐Targeted Polydopamine Nanocomposite with AIE Photosensitizer for Image‐Guided Photodynamic and Photothermal Tumor Ablation

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 15; no. 30; pp. e1902352 - n/a
• Main Authors: Chen, Yuzhi, Ai, Wenting, Guo, Xuan, Li, Yawen, Ma, Yufan, Chen, Lifang, Zhang, Hui, Wang, Tongxin, Zhang, Xin, Wang, Zhuo
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2019
• Subjects: Ablation; aggregation‐induced emission; antitumor agents; Mitochondria; mitochondria‐target; Nanocomposites; Nanomaterials; Nanoparticles; Nanotechnology; Photodynamic therapy; photodynamic‐photothermal synergetic therapeutics; photosensitizers; Target recognition; Tumors; aggregation-induced emission; photodynamic-photothermal synergetic therapeutics; mitochondria-target; photosensitizers; antitumor agents
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201902352

Photodynamic therapy (PDT) and photothermal therapy (PTT) are two kinds of treatment for tumors. Herein, a new aggregation‐induced emission (AIE)gen (MeO‐TPE‐indo, MTi) is synthesized with a D–π–A conjugated structure. MTi, which has an electron donor and an acceptor on a tetraphenylethene (TPE) conjugated skeleton, can induce the effective generation of reactive oxygen species (ROS) for PDT. With the guide of the indolium group, MTi can target and image mitochondrion selectively. In order to get good dispersion in water and long‐time retention in tumors, MTi is modified on the surface of polydopamine nanoparticles (PDA NPs) to form the nanocomposite (PDA‐MeO‐TPE‐indo, PMTi) by π–π and hydrogen interactions. PMTi is a nanoscale composite for imaging‐guided PDT and PTT in tumor treatment, which is constructed with AIEgens and PDA for the first time. The organic functional molecules are combined with nanomaterials for building a multifunctional diagnosis and treatment platform by utilizing the advantages of both sides. As a new aggregation‐induced emission (AIE)gen with a D–π–A conjugated structure, MTi has an electron donor and an acceptor on a tetraphenylethene conjugated skeleton, which induce the effective generation of singlet oxygen for photodynamic therapy (PDT). After the modification of MTi on the surface of polydopamine, a multifunctional nanocomposite is developed by combining photothermal therapy (PTT) and PDT based on a mitochondrial‐targeting nanoagent.